Efficacy and safety of central compartment neck dissection for recurrent thyroid carcinoma.

Objective: To explore the safety and efficacy of central compartment neck dissection (CCND) in the treatment of well-differentiated thyroid carcinoma (WDTC) recurrences in the central compartment of the neck.

Design: Retrospective medical chart review.

Setting: Tertiary-care academic hospital.

Decision making for the extent of thyroidectomy in the patient with atypical cytologic results.

Objective: to identify additional preoperative factors that could reliably be used to aid in determining the appropriate extent of thyroidectomy.

Design: retrospective chart review.

Setting: tertiary care academic hospital.

Thyroid cancer outcomes in Filipino patients.

Objective: To compare the outcomes of patients having thyroid cancer among Filipinos vs non-Filipinos.

Design: Retrospective medical record review.

Setting: High-volume tertiary referral center in Toronto, Ontario, Canada.

Prognostic factors in patients with multiple recurrences of well-differentiated thyroid carcinoma.

Introduction. Patients with multiple recurrences of well-differentiated thyroid carcinoma (WDTC) have markedly reduced overall survival when compared with those who have View Article and Find Full Text PDF

Influence of previous radiation exposure on pathologic features and clinical outcome in patients with thyroid cancer.

Objective: To determine whether previous radiation exposure to the head and neck is related to less favorable pathologic and clinical outcome in patients after surgical management of thyroid cancer.

Design: Retrospective chart review.

Setting: Academic teaching hospital (referral center).

Risk factors for well-differentiated thyroid carcinoma in patients with thyroid nodular disease.

Objectives: Evaluate current accepted risk factors for well-differentiated thyroid carcinoma, and develop a predictive model to determine one's risk of malignancy given a thyroid nodule.

Study Design: Retrospective analysis of 600 patients.

Subjects And Methods: Patients with benign thyroid nodular disease and with well-differentiated thyroid cancer were randomly selected.

Cost savings of patients with a MACIS score lower than 6 when radioactive iodine is not given.

Objective: To assess the cost savings if the current policy of treating patients with a MACIS (metastases, age, completeness of resection, invasion, and size) score lower than 6 using radioactive iodine (RAI) was changed to reflect the findings of recent studies.

Design: Retrospective medical record review.

Setting: Mount Sinai Hospital, Toronto, Ontario.

Extrathyroidal extension in well-differentiated thyroid cancer: macroscopic vs microscopic as a predictor of outcome.

Objective: To examine the prognostic difference in well-differentiated thyroid cancer between macroscopic extrathyroidal extension (ETE), which is appreciated in the operating room, vs microscopic ETE, which is only appreciated under the microscope by the pathologist.

Design: Retrospective medical record review.

Setting: Tertiary care academic hospital.

Quality of life in patients undergoing thyroid surgery.

Objective: The extent of thyroidectomy in the management of low-risk, well-differentiated thyroid carcinoma (WDTC) has been debated extensively. Our objective was to determine if hemithyroidectomy has a less detrimental effect on quality of life (QOL) than total thyroidectomy.

Design: Prospective, nonblinded, nonrandomized, cohort study.

Three-week thyroxine withdrawal: a thyroid-specific quality of life study.

Objectives/hypothesis: The purpose of this study is to determine the impact of a 3-week T4 withdrawal test on the quality of life (QOL) of patients undergoing investigation for residual/recurrent well-differentiated thyroid cancer.

Study Design: Prospective survey study.

Methods: 181 patients with well-differentiated thyroid cancer were surveyed using a thyroid-specific QOL-thyroid survey at three times throughout the study: prior to T4 withdrawal, after the 3-week withdrawal period, and 4 weeks after resuming T3/T4 combination therapy.

Risk of malignancy in Filipinos with thyroid nodules--a matched pair analysis.

Background: Ethnicity is an infrequently cited risk factor for thyroid cancer. This study aims to determine whether patients of Filipino origin assessed at a tertiary referral center are at increased risk of thyroid cancer and to quantify that risk.

Methods: This is a retrospective analysis of 72 Filipino patients with thyroid nodules undergoing thyroidectomy individually matched to 72 controls according to demographics, risk factors, and pre-referral investigations.

Variables predicting distant metastases in thyroid cancer.

Objectives: Distant metastases from thyroid cancer are uncommon and have a variable prognosis. We present a series of patients with distant metastases to determine which patients are at risk of developing distant disease and to examine the significant prognostic variables.

Study Design: Retrospective chart review of 30 patients with distant metastases compared with 633 controls from the Mount Sinai Thyroid Cancer Database and literature review.

Prognostic factors in well-differentiated thyroid carcinoma.

Objectives: To test the prognostic significance of standard clinicopathologic factors in patients with well-differentiated thyroid carcinoma (WDTC).

Study Design: A retrospective chart review of the thyroid cancer database at Mount Sinai Hospital (Toronto, Canada 1963-2000) was carried out.

Methods: All patients consecutively treated for WDTC with a follow-up period of at least 5 years were eligible for inclusion.

Management and outcome of recurrent well-differentiated thyroid carcinoma.

Background: The AMES (age, distant metastasis, tumor extent, and size), AGES (age, tumor size, histologic grade, tumor extent, distant metastasis), and MACIS (distant metastasis, age, completeness of primary tumor resection, local invasion, and tumor size) prognostic systems for well-differentiated thyroid carcinoma (WDTC) are well known. The development of disease recurrence is associated with a poor outcome; however, the prognostic importance of multiple treatment failures has not been clearly reported.

Objectives: To identify patient, tumor, and treatment factors that may be associated with the development of multiple recurrences in WDTC.

Clinical course of thyroid carcinoma after neck dissection.

Objectives/hypothesis: The objective was to compare the rate and site of recurrences in patients with well-differentiated thyroid carcinoma who underwent a central compartment dissection, a posterolateral neck dissection, or a combination of both procedures.

Study Design: Retrospective chart review.

Methods: The charts of 522 consecutive patients with well-differentiated thyroid carcinoma were reviewed, and 74 patients who had undergone a neck dissection were identified.

Predictive value of serum thyroglobulin after surgery for thyroid carcinoma.

Objective: To determine the relationship between stimulated serum thyroglobulin levels (taken 3 months after total thyroidectomy) and tumor stage and recurrence in patients with well-differentiated thyroid carcinoma.

Study Design: Retrospective chart review in a tertiary care institution.

Methods: Two hundred thirteen consecutive patients with well differentiated thyroid carcinoma treated between 1983 and 1998 were identified.

Impact of nodal metastases on prognosis in patients with well-differentiated thyroid cancer.

Objectives: To study the clinical and pathological variables predicting lymph node metastases in patients with well-differentiated thyroid carcinoma and to examine the impact of these metastases on recurrence and survival.

Design: Cohort study. Median follow-up, 56 months.