Splenectomy for complications of chronic granulocytic leukaemia.

13 patients with chronic granulocytic leukaemia (C.G.L.

Cytogenetic studies of the spleen in chronic granulocytic leukaemia.

Using a technique of short-term in vitro culture, cytogenetic studies were performed on splenic tissue from 12 patients with chronic granulocytic leukaemia. In eight patients the disease was in its chronic phase and had been treated with busulphan (seven cases) or splenic irradiation (one case). In five of these patients, small numbers of dividing cells possessing the Philadelphia (Ph1) chromosome were observed; in one, only Ph1 -negative metaphases, presumably those of lymphocytes, occurred, and in two patients no dividing cells were obtained.

Neutrophil alkaline phosphatase score in chronic granulocytic leukaemia: effects of splenectomy and antileukaemic drugs.

Staining with naphthol AS phosphate and Fast Blue BB salt has been used for the estimation of neutrophil alkaline phosphatase (NAP) scores in patients with chronic granulocytic leukaemia (CGL). The very low scores found at diagnosis rise when the disease is treated, and there is some inverse correlation between the NAP score and the absolute neutrophil count. Patients treated intensively developed high NAP scores.

Thioguanine as primary treatment for chronic granulocytic leukaemia.

In an attempt to convert the bone-marrow population from Philadelphia-chromosome (Ph-1) positivt to partially or wholly Ph-1 negative, thioguanine was used as primary therapy in seven patients with chronic granulocytic leukaemia (C.G.L.

Chronic granulocytic leukaemia in pregnancy.

In an era when the use of ionizing radiations for the treatment of chronic granulocytic leukaemia has largely been supplanted by therapy with busulphan or other drugs, there still exist situations where irradiation is the preferred method of initial treatment. One such situation is the unusual conjunction of chronic granulocytic leukaemia and pregnancy. Chronic granulocytic leukaemia (CGL) was diagnosed in two young women during early pregnancy as a result of routine blood examinations.

Granulocyte transfusions in treatment of infections in patients with acute leukaemia and aplastic anaemia.

By use of the continuous-flow blood-cell separator 137 bags of granulocyte-rich plasma were obtained from normal donors (59 bags) and patients with chronic granulocytic leukaemia (C.G.L.

Chronic granulocytic leukaemia: effect of elective splenectomy on the course of disease.

Conventional treatment by drugs or irradiation produces little prolongation of life in patients with chronic granulocytic leukaemia (C.G.L.

Indications for systemic antibiotic prophylaxis in neutropenic patients.

Four patients with malignant blood disease and neutropenia developed apparently localized infective lesions of the skin or conjunctiva from which Pseudomonas aeruginosa was cultured. In spite of appropriate local antimicrobial treatment all patients developed pseudomonas septicaemia within a short period and three died. It is argued that the isolation of pseudomonads from apparently localized lesions in patients with compromised antibacterial defences is an indication for systemic antibiotic therapy.

Chronic granulocytic leukaemia: multiple-drug chemotherapy for acute transformation.

The response to 60 trials of therapy in 50 patients with chronic granulocytic leukaemia (C.G.L.

Diabetes insipidus and marked elevation of foetal haemoglobin in a case of acute leukaemia.

A case of acute myelomonocytic leukaemia is described in which diabetes insipidus was the presenting symptom.