Publications by authors named "Spencer Tang"
The mammalian olfactory system consists of sensory neurons with specialized odorant-binding capability accomplished by mutually exclusive odorant receptor (OR) expression. Mutually exclusive OR expression is a complex multi-step process regulated by a number of cis and trans factors, including pan-silencing of all OR genes preceding the robust and stable expression of the one OR selected in each sensory neuron. We transfected two olfactory-placode-derived cell lines modeling immature odorant sensory neurons, as well as the GD25 fibroblast cell line, with episomes containing CMV-driven GFP and TK-driven hygromycin reporter genes.
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- - Drosophila sechellia, a fruit fly native to the Seychelles, has adapted to eat the toxic fruit of Morinda citrifolia by developing resistance to its harmful compounds, octanoic and hexanoic acids.
- - Research is focused on how D. sechellia has evolved resistance specifically to hexanoic acid, as previous studies have primarily tackled octanoic acid resistance.
- - By exposing D. sechellia and related species to hexanoic acid and analyzing their gene expression, the study found that while generalist flies activated many detoxification genes, D. sechellia downregulated immune-related genes, revealing unique adaptations to its specialized diet.