Strategies for Therapeutic Amelioration of Aberrant Plasma Zn Handling in Thrombotic Disease: Targeting Fatty Acid/Serum Albumin-Mediated Effects.

The initiation, maintenance and regulation of blood coagulation is inexorably linked to the actions of Zn in blood plasma. Zn interacts with a variety of haemostatic proteins in the bloodstream including fibrinogen, histidine-rich glycoprotein (HRG) and high molecular weight kininogen (HMWK) to regulate haemostasis. The availability of Zn to bind such proteins is controlled by human serum albumin (HSA), which binds 70-85% of plasma Zn under basal conditions.