A comparative study of freeze-drying heat transfer in polymeric vials and glass vials.

Implementation of polymeric vials for freeze-dried drug products has been practically non-existent because of unique moisture barrier and thermodynamic technical challenges. Hybrid vials, which combine the benefits of polymer and glass, have been shown to address the challenges of ordinary polymeric vials. Tackling thermodynamic challenges starts with a clear understanding of the heat transfer mechanism.

Volumetric Evaluation of 5 Root Canal Obturation Methods in TrueTooth 3-dimensional-Printed Tooth Replicas Using Nano-computed Tomography.

Introduction: The aim of this study was to evaluate the volumes of total obturation and voids in different obturation techniques using nano-computed tomographic imaging. The null hypothesis was that the obturation technique and the materials used have no effect on the total volume of obturation or the total volume of voids.

Methods: Fifty maxillary left central incisor 3-dimensional-printed replicas (TrueTooth; Dental Engineering Laboratories, Santa Barbara, CA) were instrumented and randomly assigned to 5 different obturation groups (n = 10): single cone with EndoSequence Gutta-Percha Points (Brasseler USA, Savannah, GA) and Ribbon Sealer (Dentsply Sirona, Tulsa, OK) (SC1), single cone with BC 150 Series Gutta-Percha Points (Brasseler USA) and EndoSequence BC Sealer (Brasseler USA) (SC2), continuous wave with EndoSequence Gutta-Percha Points and Ribbon Sealer (CW), GuttaCore carrier obturation (Dentsply Sirona) and Ribbon Sealer (GC), and cold lateral condensation with EndoSequence Gutta-Percha Points and Ribbon Sealer (CL).