Corrigendum: Evolution, ecology, and zoonotic transmission of betacoronaviruses: a review.

[This corrects the article DOI: 10.3389/fvets.2021.

Corrigendum: Evolution, ecology, and zoonotic transmission of betacoronaviruses: A review.

[This corrects the article DOI: 10.3389/fvets.2021.

Evolution, Ecology, and Zoonotic Transmission of Betacoronaviruses: A Review.

Coronavirus infections have been a part of the animal kingdom for millennia. The difference emerging in the twenty-first century is that a greater number of novel coronaviruses are being discovered primarily due to more advanced technology and that a greater number can be transmitted to humans, either directly or an intermediate host. This has a range of effects from annual infections that are mild to full-blown pandemics.

Comparing regression and neural network techniques for personalized predictive analytics to promote lung protective ventilation in Intensive Care Units.

Mechanical ventilation is a lifesaving tool and provides organ support for patients with respiratory failure. However, injurious ventilation due to inappropriate delivery of high tidal volume can initiate or potentiate lung injury. This could lead to acute respiratory distress syndrome, longer duration of mechanical ventilation, ventilator associated conditions and finally increased mortality.

Incremental Density-Based Clustering on Multicore Processors.

The density-based clustering algorithm is a fundamental data clustering technique with many real-world applications. However, when the database is frequently changed, how to effectively update clustering results rather than reclustering from scratch remains a challenging task. In this work, we introduce IncAnyDBC, a unique parallel incremental data clustering approach to deal with this problem.

QSAR ligand dataset for modelling mutagenicity, genotoxicity, and rodent carcinogenicity.

Five datasets were constructed from ligand and bioassay result data from the literature. These datasets include bioassay results from the Ames mutagenicity assay, Greenscreen GADD-45a-GFP assay, Syrian Hamster Embryo (SHE) assay, and 2 year rat carcinogenicity assay results. These datasets provide information about chemical mutagenicity, genotoxicity and carcinogenicity.

Combining machine learning models of in vitro and in vivo bioassays improves rat carcinogenicity prediction.

In vitro genotoxicity bioassays are cost-efficient methods of assessing potential carcinogens. However, many genotoxicity bioassays are inappropriate for detecting chemicals eliciting non-genotoxic mechanisms, such as tumour promotion, this necessitates the use of in vivo rodent carcinogenicity (IVRC) assays. In silico IVRC modelling could potentially address the low throughput and high cost of this assay.

The Effects of Spatial Endogenous Pre-cueing across Eccentricities.

Frequently, we use expectations about likely locations of a target to guide the allocation of our attention. Despite the importance of this attentional process in everyday tasks, examination of pre-cueing effects on attention, particularly endogenous pre-cueing effects, has been relatively little explored outside an eccentricity of 20°. Given the visual field has functional subdivisions that attentional processes can differ significantly among the foveal, perifoveal, and more peripheral areas, how endogenous pre-cues that carry spatial information of targets influence our allocation of attention across a large visual field (especially in the more peripheral areas) remains unclear.

Depression and cardiac dysautonomia in eating disorders.

Purpose: Individuals with eating disorder (ED) are at an increased risk of cardiac arrhythmias due to cardiac dysautonomia, which may be exacerbated if depression is also present. The aim of the study was to use heart rate analysis as a marker for cardiac dysautonomia in patients with eating disorders and depression as a comorbidity.

Methods: Clinical data, including presence of depression, was obtained from all participants.

The Commingled Division of Visual Attention.

Many critical activities require visual attention to be distributed simultaneously among distinct tasks where the attended foci are not spatially separated. In our two experiments, participants performed a large number of trials where both a primary task (enumeration of spots) and a secondary task (reporting the presence/absence or identity of a distinctive shape) required the division of visual attention. The spots and the shape were commingled spatially and the shape appeared unpredictably on a relatively small fraction of the trials.

Upper visual field advantage in localizing a target among distractors.

Biases exist in many perceptual and cognitive functions. Since visual attention plays an important role in a wide range of perceptual and cognitive processes, any bias in the spatial distribution of attention is likely to be a significant source of perceptual and cognitive asymmetries. An attentional visual field task (AVF) requiring localization of a target among distractors was used to assess possible asymmetries in attentional processing in the vertical meridian.

Playing shooter and driving videogames improves top-down guidance in visual search.

Playing action videogames is known to improve visual spatial attention and related skills. Here, we showed that playing action videogames also improves classic visual search, as well as the ability to locate targets in a dual search that mimics certain aspects of an action videogame. In Experiment 1A, first-person shooter (FPS) videogame players were faster than nonplayers in both feature search and conjunction search, and in Experiment 1B, they were faster and more accurate in a peripheral search and identification task while simultaneously performing a central search.

A mixture distribution of spatial attention.

Although it may seem paradoxical, the unified-focus and multiple-foci theories of spatial selective attention are both well supported by experimental evidence. However, the apparent contradiction is illusory and the two competing views may be reconciled by a closer examination of the spatial mechanisms involved. We propose that the deployment of attention may be modeled as a mixture of individual distributions of attention and we tested this hypothesis in two experiments.

Attention and visuospatial working memory share the same processing resources.

Attention and visuospatial working memory (VWM) share very similar characteristics; both have the same upper bound of about four items in capacity and they recruit overlapping brain regions. We examined whether both attention and VWM share the same processing resources using a novel dual-task costs approach based on a load-varying dual-task technique. With sufficiently large loads on attention and VWM, considerable interference between the two processes was observed.

Playing a first-person shooter video game induces neuroplastic change.

Playing a first-person shooter (FPS) video game alters the neural processes that support spatial selective attention. Our experiment establishes a causal relationship between playing an FPS game and neuroplastic change. Twenty-five participants completed an attentional visual field task while we measured ERPs before and after playing an FPS video game for a cumulative total of 10 hr.

Acute antioxidant supplementation improves endurance performance in trained athletes.

This study examined the acute effects of a single dose of an antioxidant (AO; Lactaway® containing pycnogenol) on time to fatigue (TTF). Nine trained cyclists [mean ± SD age 35 ± 10 yrs; body mass 71.6 ± 10.

Increased total heart rate variability and enhanced cardiac vagal autonomic activity in healthy humans with sinus bradycardia.

Sinus bradycardia can be defined as a sinus rhythm with a resting heart rate of 60 beats per minute or less. While it is assumed that increased autonomic parasympathetic activity is associated with sinus bradycardia, such an association has yet to be proven. The aims of this study were to compute a number of heart rate variability (HRV) parameters in healthy individuals with sinus bradycardia and determine whether there was a significant vagal component to sinus bradycardia.

A serotoninergic basis for hyperphagic eating changes in Alzheimer's disease.

Hyperphagia and associated eating changes occur frequently in Alzheimer's disease (AD) and lead to considerable morbidity. However, the neurochemical basis for these neuropsychiatric behaviours is at present unclear. In this study, we measured serotonin transporters, 5-HT(1A), 5-HT(2A), and 5-HT(4) receptors using radioligand binding assays in the postmortem temporal cortex of a cohort of controls and AD patients longitudinally assessed for hyperphagia.

Women match men when learning a spatial skill.

Meta-analytic studies have concluded that although training improves spatial cognition in both sexes, the male advantage generally persists. However, because some studies run counter to this pattern, a closer examination of the anomaly is warranted. The authors investigated the acquisition of a basic skill (spatial selective attention) using a matched-pair two-wave longitudinal design.

Immunization with a synthetic robustoxin derivative lacking disulphide bridges protects against a potentially lethal challenge with funnel-web spider (Atrax robustus) venom.

The venom of male Atrax robustus spiders is potentially lethal to primates. These spiders have been responsible for a number of human deaths. Robustoxin is the lethal toxin in the venom.

Role of inhibition in chronic cerebral hypoperfusion.

Chronic reductions in cerebral blood flow (CBF) of between 25 and 50% maintained for 26 weeks impair neuronal function, through a mechanism which is not known, but which is now explored. Increased GABAergic synaptic inhibition may play a role, as inhibitory interneurons are known to be relatively resistant to acute ischaemic insults. The phenomenon of tetanus-induced longterm potentiation (LTP) was previously found to be impaired in this setting, and was thus examined in the in vitro rat hippocampus in the presence of bicuculline, a specific GABA(A) antagonist, to evaluate the role of inhibition in the impairment of LTP in chronic cerebral hypoperfusion (CCH).

Long-term potentiation saturation in chronic cerebral hypoperfusion.

Chronic reductions in cerebral blood flow (CBF) of between 25 and 50%, in the absence of cerebral infarction, lead to impairments in hippocampal in vitro long-term potentiation (LTP). This study set out to explore some of the properties of this impairment of LTP. LTP is an electrophysiological property known to occur in the hippocampus, a region known to be exquisitely sensitive to hypoxic or ischemic insults.

Chronic high dose captopril decreases total heart rate variability and increases heart rate in C57BL/6J mice.

The effects of high dose captopril, within the therapeutic range, on autonomic activity are unknown in those with normal cardiovascular function. Thus the study aims were to assess the effects of high dose captopril on autonomic function in mice. Autonomic activity was measured using heart rate variability (HRV).

A novel methodology to probe endothelial differential gene expression profile reveals novel genes.

Endothelial dysfunction is a major feature of vascular diseases. A practical, minimally invasive method to effectively "probe" gene transcription for an individual patient's endothelium has potential to "customize" assessment for an individual at risk of vascular disease as well as pathophysiologic insight in an in vivo human, clinical context. Published literature lacks a methodology to identify endothelial differential gene expression in individuals with vascular disease.

Playing an action video game reduces gender differences in spatial cognition.

We demonstrate a previously unknown gender difference in the distribution of spatial attention, a basic capacity that supports higher-level spatial cognition. More remarkably, we found that playing an action video game can virtually eliminate this gender difference in spatial attention and simultaneously decrease the gender disparity in mental rotation ability, a higher-level process in spatial cognition. After only 10 hr of training with an action video game, subjects realized substantial gains in both spatial attention and mental rotation, with women benefiting more than men.