Publications by authors named "Spela Suler Baglama"

Article Synopsis
  • Lichen sclerosus (LS) has not been thoroughly analyzed for its associated health conditions, leading to this review's goal of identifying comorbidities and considering sex-specific screening needs.
  • A systematic search of medical databases revealed 21 relevant case-control studies, analyzing 75 comorbidities but finding only 16 studied in both sexes without differing associations.
  • Both male and female LS patients showed increased odds of various common skin conditions and cardiovascular risk factors, highlighting the need for attentive clinical monitoring despite the lack of evidence supporting sex-dependent screening.
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The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the development of further drugs for treatment of AK. A number of other chemotherapeutics have thus been linked to similar reactions without ensuing development.

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Background: Inflammation of actinic keratoses (AK) was originally described with systemic 5-fluorouracil, and led to the development of topical fluorouracil. Similar observations using different chemotherapeutics may point to other drugs with a potential for repositioning.

Objective: This systematic review aims to evaluate chemotherapeutic agents linked to inflammation-induced cure of AK.

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The human body is inhabited by complex communities of microorganisms. Changes in the composition and function of the skin and gut microbiota are linked to various skin diseases. The microbiota is an important modulator of the immune system and thus maintains homeostasis.

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This patient presented with a 1-year history of violaceous-brown, coalescing reticulated macules on his face, with no similar lesions in other body areas. Laboratory findings were normal and antinuclear antibody test was negative. Histopathological findings included lichenoid tissue reaction and prominent pigmentary incontinence.

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Palisaded neutrophilic granulomatous dermatitis (PNGD) is a rare histopathological pattern belonging to a group of cutaneous granulomatous eruptions that typically manifests with asymptomatic skin-colored, erythematous, or violaceous papules or nodules. PNGD can be triggered by various systemic conditions, including medications and autoimmune and autoinflammatory disorders, as well as malignancies; for example, lymphoproliferative disorders. Therefore, in patients with PNGD an extended diagnostic workup is mandatory as well as follow-up in the case of idiopathic PNGD.

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Psoriasis is a chronic immune-mediated skin disease that affects 125 million people worldwide. Over the last two decades, biologic drugs have revolutionized the treatment of moderate to severe plaque psoriasis. They act on one or more molecular targets and thus modify or inhibit signal transduction pathways in the pathophysiological process of the disease.

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