Clinical and nasal biopsy response to treatment of perennial rhinitis.

Nasal biopsies of patients with perennial rhinitis were performed at baseline and compared with biopsies performed 4 wk after active flunisolide, 50 micrograms four times per day, or placebo. An effort was made to relate histologic findings to other subjective and objective parameters as an indication of response to treatment. Although patients admitted to the study had severe subjective nasal symptoms, biopsies varied considerably.

Role of central cholinergic neurons in experimental hypertension.

Intravenous injection of the cholinesterase inhibitor physostigimine evoked a hypertensive response in the unanesthetized 12- to 14-week-old spontaneously hypertensive rat (SHR). These responses were greatly enhanced in magnitude when compared to similar injections in normotensive Wistar-Kyoto (WKY) control rats. Stimulation of autonomic ganglia with dimethylphenylpiperazinium (DMPP) also evoked a pressor response in SHR; however, the magnitude of these responses was not different from those obtained in WKY.

Is resistance of a muscle to fatigue controlled by its motoneurones?

The original experiment of Buller et al. and the many subsequent confirmatory reports clearly show that the time-to-peak tension and many other speed-related parameters of slow and fast muscle fibres are dictated by the motoneurone. It has been concluded that the motoneurone exerts this control of the physiological and associated biochemical properties by the frequency at which it excites the muscle fibre.

Influence of clonidine on experimental hypertension induced by cholinergic stimulation.

Hypertension may be induced by pharmacologic activation of central cholinergic receptors either indirectly, through the injection i.v. of physostigmine, or directly, through the injection of i.

Pharmacokinetics of d-tubocurarine in man: effect of an osmotic diuretic on urinary excretion.

The pharmacokinetics of d-tubocurarine (dTc) and the urinary excretion of dTc were studied in 18 neurosurgical patients with normal renal function, over a period of 96 hours. The effects of an osmotic diuretic (mannitol) on urinary elimination of dTc were determined. Following a single intravenous dose of d-tubocurarine (dTc, 0.

Nurse training and staffing in the neonatal intensive care unit.

Most nurses are unfamiliar with the highly sophisticated level of technology that must be utilized in the delivery of care in an NICU. This article has presented the measures that are utilized at one medical center to provide the nursing staff for its NICU. The presentation focused on the organization, selection, and development of a nursing staff that is capable of delivering a sophisticated level of care to sick neonates.

Isolated brain microvessels: preparation, morphology, histamine and catecholamine contents.

A method for the rapid preparation of parenchymal microvessels from rat, rabbit and bovine brains is described. Light and electron microscopic examination of the isolated microvessels showed the smooth muscle and endothelial cells to be intact and substantially free of neutrophil contamination. The observation of 0.

Mechanism of the antihypertensive action of clonidine on the pressor response to physostigmine.

Physostigmine (P) was used as a model in anesthetized rats for the development of hypertension by a central cholinergic mechanism. P (25-100 micrograms/kg i.v.

Aspirin and concomitant idiosyncrasies in adult asthmatic patients.

The nasal and respiratory symptoms observed after oral challenge to aspirin (ASA), tartrazine, and other nonsteroidal anti-inflammatory substances are best described as idiosyncratic reactions. A positive response to oral challenge, defined as a 20% fall in forced expiratory volume in 1 sec (FEV1) from baseline for up to 4 hr, occurred in 44 of 230 patients with ASA, 11 of 277 with tartrazine, 2 of 93 with sodium salicylate, and 2 of 69 with acetaminophen. No one had a positive response to tartrazine, sodium salicylate, or acetaminophen who was not also positive to ASA.

Relationship between airways response to allergens and nonspecific bronchial reactivity.

Bronchial inhalation challenges to histamine, methacholine, and at least one antigen were performed on 183 asthmatic patients who previously had received skin tests to at least 16 different antigens. Individuals with a positive skin test and a positive antigen inhalation challenge to the same antigen had lower thresholds of response to both histamine and methacholine. This pattern was statistically significant for mixed trees, mixed grasses, mixed molds, and house dust but not for mixed ragweed.

Cytomegaloviruria in older infants in intensive care nurseries.

Over a four-month period, urine specimens for viral isolation were obtained weekly from all infants older than three weeks in two intensive care nurseries. These babies comprised 43% of the patients in the nurseries surveyed. Cytomegalovirus was cultured from 13 of 93 (14%) of these infants.

Effect of guanethidine on collagen biosynthesis in blood vessels of hypertensive rats.

The effect of guanethidine on collagen biosynthesis in the aorta and mesenteric artery was investigated in desoxycorticosterone acetate (DOCA)-salt hypertensive rats. Prolyl hydroxylase activity (EC 1.14.

Effect of a selective beta 2 adrenergic agonist and theophylline on skin test reactivity and cardiovascular parameters.

Fenoterol, a selective beta 2-adrenergic agent, and aminophylline in the "therapeutic range" were compared with placebo for their inhibitory effect on skin test reactivity to allergens and histamine. Cardiovascular parameters were also assessed. A new, inexpensive micrometer adaptor to a tuberculin syringe was used to deliver allergens and histamine more accurately.

Methacholine and histamine inhalation challenges in asthma: relationships to age of onset, length of illness, and pulmonary functions.

Levels of airways hyperreactivity, as indexed by methacholine and histamine thresholds, were determined for hospitalized asthmatic patients using the serial concentration, constant-breath method. Airways hyperreactivity was categorized into low and high based on a split of the sample of subjects tested. These categories were unrelated to pulmonary function measurements obtained throughout hospitalization.