Effects of pentylenetetrazol on resting membrane potential and on action potentials of mammalian dorsal root ganglion cells grown in tissue culture.

The effects of pentylenetetrazol (PTZ) on resting membrane potential (RMP) and on action potentials (AP) of dorsal root ganglion cells of the rat in tissue culture were studied. PTZ usually evoked a hyperpolarization which was followed by a depolarization. The hyperpolarization diminished with increasing initial MP and was absent at about 80 mV.

Diet, nutrition, and cancer.

As the second leading cause of death in the United States, cancer is a major public health problem today. Cancer incidence varies worldwide and tends to change with migration. These epidemiological observations have led to the concept that environmental factors may be important in carcinogenesis.