Publications by authors named "Spears A"

Article Synopsis
  • The study investigates how daily breathing patterns, or minute ventilation, are regulated by both the body's circadian clock and external light conditions, specifically through a type of retinal cell known as Brn3b-expressing ipRGCs.
  • Mice exposed to a non-standard light cycle (14 hours light and 14 hours dark) demonstrated a 28-hour rhythm in their breathing patterns, peaking at the onset of darkness, which was linked to their physical activity.
  • When tested, mice lacking the Brn3b-expressing ipRGCs maintained a consistent 24-hour rhythm in breathing, indicating that external light cues can influence ventilation rhythms even when the body's internal clock is not perfectly aligned.
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Background: Stigma is a barrier to treatment and harm reduction seeking in people who use drugs. Most stigma reduction interventions offer psychotherapy or psychoeducation in group-based clinical settings, failing to reach people who are not in treatment. SMS text messaging is an effective and acceptable modality for delivering health information to people who use drugs and may be a suitable conduit for providing information and advice to understand and cope with stigma.

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Article Synopsis
  • * Researchers conducted a spatial survey using an underwater vehicle in a specific area of the Ross Ice Shelf, revealing ice melting and freezing dynamics in the basal crevasse.
  • * Findings indicate that these basal crevasses significantly alter ocean circulation and mixing at grounding zones, suggesting a complex interaction previously underestimated.
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While the suprachiasmatic nucleus (SCN) controls 24-h rhythms in breathing, including minute ventilation (V), the mechanisms by which the SCN drives these daily changes are not well understood. Moreover, the extent to which the circadian clock regulates hypercapnic and hypoxic ventilatory chemoreflexes is unknown. We hypothesized that the SCN regulates daily breathing and chemoreflex rhythms by synchronizing the molecular circadian clock of cells.

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A series of pseudorotaxanes with supramolecular organometallic silver(I) and gold(I) pillarplexes acting as rings and different α,ω-dicarboxylic acids as axle components are reported. The successful formation of the host-guest complexes is shown by H NMR spectroscopy and respective NMR titration. Additional evaluation with ITC titration experiments yielded dissociation constants (K ) ranging from 10 to 10  M.

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The COVID-19 pandemic impacted emotional well-being due to safety concerns, grief, employment impacts, and social interaction limitations. Face-to-face mental health treatment restrictions were especially impactful to veterans who often gain social enrichment from Veterans Health Administration (VHA) care. We present results from a novel group-based telehealth intervention, VA Caring for Our Nation's Needs Electronically during the COVID-19 Transition (VA CONNECT), which integrates skills training and social support to develop a COVID-19 Safety & Resilience Plan.

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Article Synopsis
  • Ice streams contribute about 10% of the mass flux from West Antarctica, but Kamb Ice Stream has been stagnant since the late 1800s, causing grounding-line retreat at its transition to the floating Ross Ice Shelf.
  • Understanding the relationships between ice sheets, ocean conditions, and sea level is challenging due to the remoteness of these areas, but recent in situ observations help clarify these interactions.
  • Researchers used an underwater vehicle to uncover complex ice-ocean interactions, including a near-freezing water layer at the ice base and evidence of past grounding-line changes through features like crevasse impressions on the seafloor.
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Thwaites Glacier represents 15% of the ice discharge from the West Antarctic Ice Sheet and influences a wider catchment. Because it is grounded below sea level, Thwaites Glacier is thought to be susceptible to runaway retreat triggered at the grounding line (GL) at which the glacier reaches the ocean. Recent ice-flow acceleration and retreat of the ice front and GL indicate that ice loss will continue.

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Background: The population of people living with HIV is aging, and with aging come emergent comorbidities, including osteoporosis, for which screening and treatment are becoming increasingly important. Osteoporosis prevalence among those living with HIV is 3 times greater than among HIV-uninfected controls.

Objective: To assess and describe osteoporosis risk factors, screening, diagnosis, and treatment for people 50 years of age or older living with HIV and receiving care at a multidisciplinary HIV primary care clinic.

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A growing body of evidence supports the need for health systems to shift towards addressing social determinants of health (SDoH) as part of routine care. However, little is known about the state of the industry in terms of procurement and use of SDoH data. To assess stakeholders' perceptions and experiences in collecting and utilizing SDoH data.

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Background: The lack of diversity in the health workforce is partly due to selection criteria for health professional programmes that have not selected students from a wide range of backgrounds. Consequently, health care professionals from minority groups and lower socio-economic backgrounds are under-represented in the workforce.

Approach: The Socioeconomic Equity (EQ) support programme aims to increase the participation, retention and academic success of students from low socio-economic communities studying in health professional programmes at the University of Otago.

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COVID-19 has transformed day-to-day functioning and exacerbated mental health concerns. The current study examines preliminary feasibility and acceptability of a VA CONNECT - a novel 10-session, manualized telehealth group intervention integrating skills training and social support to develop a Safety & Resilience Plan for Veterans experiencing COVID-related stress. Data from the first 20 participants support the intervention's feasibility and acceptability.

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COVID-19 has affected many people worldwide. Beyond the physical symptoms brought on by this virus, it has adversely affected those without the illness through isolation, social distancing, and changes in job and housing security. Clinicians are trying to address the mental health needs of millions of strained Americans with and without COVID-19 and are operating without a systematic strategy.

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This PRISMA scoping review explores existing research conducted with United States military samples utilizing ecological momentary assessment (EMA) to evaluate mental health outcomes. EMA facilitates understanding of temporal changes of dynamic variables subject to change difficult to capture in standard laboratory assessment. It also elucidates understanding of complex etiology of mental illness in military and veteran samples and treatment approaches.

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