Proteome Profiling of the Exhaled Breath Condensate after Long-Term Spaceflights.

Comprehensive studies of the effects of prolonged exposure to space conditions and the overload experienced during landing on physiological and biochemical changes in the human body are extremely important in the context of planning long-distance space flights, which can be associated with constant overloads and various risk factors for significant physiological changes. Exhaled breath condensate (EBC) can be considered as a valuable subject for monitoring physiological changes and is more suitable for long-term storage than traditional monitoring subjects such as blood and urine. Herein, the EBC proteome changes due to the effects of spaceflight factors are analyzed.

[Embryogenesis of the Japanese quail in hypomagnetic conditions applied to deep space flights].

During future interplanetary flights and on the lunar base, astronauts and bioregenerative systems on the space ship will occur in an interplanetary magnetic field, which is much lower than the habitual geomagnetic field (GMF). It is known that hypomagnetic conditions have an adverse biological effect on human beings and other living systems. In our research the Japanese quail has been chosen as one of the possible elements of the bioregenerative live support system.

[Effects of high energy charged particles on conduction of nerve rhythmic excitation].

The effects of heavy charged particles--alpha-particles and deuterons accelerated by cyclotron to the energies of 30.3 and 15.4 MeV accordingly--on nerve's excitability (amplitude of an action potential (AP) and speed of AP propogation has been studied.

[The systematic position of Hymenolepididae (Cestoda) from Australian marsupials].

A review of Hymenolepididae from Australian Marsupialia is given. These cestodes are transmitted out of the genus Hymenolepis, into which they were previously included. 3 species of them are transmitted to the genus Rodentolepis, and 7 species are arranged as a new genus Potorolepis.

[Rationale for maximum permissible concentration of arbidole and thiophenol in water reservoirs].

Maximum allowable concentrations (MAC) for Arbidole and thiophenoi in water were substantiated. MAC of this substances accordingly are (mg/dm3): 0.04 and 0.

[Hygienic standardization of realon and zinc complex IOMC-1 in water reservoirs].

Maximum allowable concentrations of Realon and zinc complex IOMC-1 in water were recommended at levels, accordingly, 0.04 and 2.0 mg/1 with organoleptic signs of action.

[The importance of an early stress test in patients with myocardial infarct and heart failure in the acute period of the disease].

The mechanisms of acute myocardial infarction depend on the site of myocardial infarction (MI). In anterior MI, the main factor is a large area of injury; in inferior MI, of importance is dysfunction of the papillary muscles and multiple lesions of the coronary artery in addition to the above factor. The site, the area of injury and the status of the coronary bed influence the rate, character and prognostic value of early load test criteria and contractile function of the left ventricle.

[Prognostic significance of disorders of regional left-ventricular contractility detected in the subacute period of myocardial infarction].

The predictive value of left ventricular contractility index, lesion extent, ejection fraction was examined from sector scanning data in 107 able-bodied males with primary transmural myocardial infarction (MI) complicated by left ventricular aneurysm in the acute period (in 28 patients with anterior MI) and heart failure (in 23 patients with inferior MI). The findings suggest that the severity of regional contractility disorders is associated with the location of myocardial infarction and the state of the coronary bed. The significant lesion extent and multiplicity in the coronary arteries showed a high risk for postinfarction events.

[Interrelations between obstructive changes in the coronary arteries and clinical manifestations of heart failure in patients after myocardial infarction].

The study was undertaken to examine clinical and angiographic signs in 154 patients with prior myocardial infarction. There was a relationship between the left ventricular performance and heart failure stages and the number of diseased left ventricular segments and heart failure stages. With an increase in the number of diseased left ventricular segments, cardiac contractility decreased.

[Clinical manifestations of ischemic heart disease in the subacute period of myocardial infarction and post-infarct cardiosclerosis depending on the status of coronary arteries].

Multifactor discriminant analysis was used on a computer to examine 100 patients with myocardial infarction in the subacute period (at week 4 of the disease onset) and 76 in the postinfarction period (at months 2-120 of postinfarction). A complex of clinical and coronary signs was defined, which differentiated patients with subacute myocardial infarction and postinfarct cardiosclerosis, as well as those with postinfarct stable and progressive angina pectoris.

[The value of early exercise testing in patients with myocardial infarction complicated by evolving left ventricular aneurysm].

The values of an early exercise test limited by criteria for test termination were compared with coronaro- and ventriculographic measurements made 2-3 days after the test in 51 males of working age who suffered from transmural myocardial infarction complicated by local aneurysm in 12 cases and by overall left ventricular aneurysm in 39. The exercise test performed in the early periods was found to substantially increased its sensitivity. The isolated ST-dominant segment elevation in patients with local aneurysm and isolated coronary artery lesion indicated that the patients had a favourable prognosis.

[Features of clinical manifestations of intermediate coronary syndrome in relation to the status of the coronary bed].

Uni- and multifactorial analyses of clinical and angiographic findings were made in 32 patients with coronary heart disease concurrent with the intermediate coronary syndrome and 34 patients with progressive angina pectoris. A complex of clinical and angiographic signs was defined, which enabled these groups of patients to be differentiated. Exercise tolerance was the same in the two groups and related to the severity of coronary artery lesions.

[Development of left-ventricular aneurysm in relation to the status of the coronary bed in patients with a history of myocardial infarction].

The study was undertaken to examine 270 patients with a history of myocardial infarction. Its purpose was to reveal a relationship between the ischemic signs of cardiac aneurysm and the status of coronary arteries. The findings suggested that left ventricular aneurysm was greatly due to severe obstruction of the infarct-related right intraventricular branch of a coronary artery.

[Characteristics of the clinical manifestations of stenocardia in patients with ischemic heart disease, without myocardial infarct, in relation to the state of the coronary bed].

Mono- and multifactorial discriminant analyses aided by computer were used in 106 patients with coronary disease to compare the clinical and angiographic findings common to different manifestations of angina pectoris. The relationship was discovered between the clinical form of angina pectoris and the gravity of lesions of the coronary artery. Intracardiac hemodynamics and left ventricular contractility at rest did not differ whatever the patients' group.

[Effect of physical training with reference to anaerobic threshold on the indicators of exercise tolerance and restoration of work capacity in patients after myocardial infarction].

In patients who had sustained myocardial infarction including that of complicated history, the anaerobic threshold was defined to choose the optimum intensity of physical training. The latter were also examined for effects on exercise tolerance. It was ascertained that measuring physical exercise by heart rate at the level of the anaerobic threshold made it possible to choose the optimal conditions for the aerobic supply of metabolic demands during physical training.