[EXTRACORPOREAL BLOOD CORRECTION METHODS AND THEIR IMPACT ON PRODUCTS OF MICROBIAL METABOLISM IN PATIENTS WITH SEPSIS].

Sepsis is a disease with a high death-rate and is accompanied by profound metabolic disturbances. Interference of microbe metabolic products with biochemical processes in human organism is present in case of severe infection. But there is little information about integration of microbe and human metabolism in septic patients.

[Elimination of inflammatory mediators in sepsis by means of sorption detoxification methods].

The levels of pro- and anti-inflammatory cytokines were studied in 31 patients with sepsis of varying etiology; in 17 patients of them hemosorption through the antiproteinase sorbent Ovosorb was included into a complex of traditional intensive care, in 14 patients hemocarboperfusion was made through the carbon hemosorbent Simplex-F. The sorption detoxification methods were found to cause a reduction in the excessive levels of blood inflammatory cytokines, the hemosorbent Ovosorb showing the most pronounced eliminating effect. At the same time, there was an increase in the blood level of anti-inflammatory mediators in patients on Ovosorb hemosorption.

[Effect of extracorporeal autohemomagnetic therapy on oxygen balance in patients with acute lung injury syndrome in sepsis].

The paper shows the results of a study evaluating the impact of impulse magnetic fields on the blood of patients with acute lung injury concurrent with sepsis. Extracorporeal autohemomagnetic therapy has been ascertained to reduce blood and tissue hypoxia. Thus it normalizes basic oxygen homeostasis more effectively than do traditional methods.

[Clinical course and intensive therapy of sepsis in geriatric patients].

A comparative analysis was performed of a clinical course and intensive therapy of sepsis in 43 patients over 60 years of age. 86% of them were patients aged 60 to 74 years, the rest were older. The intensive therapy included: surgical treatment of the infection focus (on demand), antibiotics, immunomodulators (immunoglobulins or interleukine-2 preparations), nonsteroid antiinflammatory drugs (diclofenak), inhibitors of tumor necrosis factor (pentoxiphilline), vitamins of group B, infusion therapy, parenteral feeding (on demand), plasmapheresis or biospecific antiproteinase hemosorption.

[Evaluation of the severity of endotoxicosis and effectiveness of detoxification therapy].

A biophysical method for assessment of hemoperfusion and intensive care efficacy in patients with endogenous intoxication syndrome is suggested. Endotoxicosis developed because of sepsis in 31 patients, because of acute hepatic insufficiency due to cholestasis, hepatitis, or mechanical jaundice in 12. Blood magnetic susceptibility was studied by Gui's method.

[Immunologic indices in patients with sepsis and their changes in response to complex intensive therapy].

Immune status has been studied in the course of intensive care in 48 patients. It has been established that hemosorption may enhance already existing changes in immune homeostasis in patients with sepsis. Therefore, immunostimulating therapy with tactivin and group B vitamins (B1, B6, B12) or ultraviolet (UV) blood irradiation in combination with group B vitamins administration have been included into therapy.

[Changes in the amino acid spectrum of the blood in patients with sepsis in the process of complex intensive therapy].

Amino acid fund has been studied during complex therapy of 25 patients with sepsis. In 15 patients complex therapy included detoxicating hemosorption (3-5 sessions), in 10 patients hemosorption was supplemented by ultraviolet blood irradiation (5-10 sessions). Complex therapy employing hemosorption led to a decrease in serine plasma level.

[Optimization of the functional activity of the adrenal cortex in patients with sepsis].

The effect of hemosorption on adrenal steroidogenic reactions has been studied in 75 patients with sepsis. Different variants of steroidogenesis optimization have been used. Hemosorption led to an increase in the level of steroid hormones, with this background retained throughout the whole treatment period.

[Changes in the amino acid spectrum pf the blood in patients with sepsis undergoing complex intensive therapy].

Amino acid fund was studied during intensive therapy of 25 patients with sepsis. In 15 patients complex therapy involved detoxicating hemosorption (3-5 sessions) and in 10 patients hemosorption was supplemented by ultraviolet blood irradiation (5-10 sessions). Complex therapy with hemosorption led to a decrease in plasma serine content.

[The effect of anesthesia on the immunoglobulin level of the blood].

The effect of halothane anesthesia, neuroleptanalgesia and ketamine anesthesia on immunoglobulin (Ig) blood level has been studied in 67 patients with gastric and duodenal ulcers subject to selective proximal vagotomy. The results obtained indicate possible reduction in humoral immunity under the influence of anesthesia and surgery. In patients operated on under halothane anesthesia there was a decrease in IgM, IgG and IgA levels.

[Thiamine prevention of the corticosteroid reaction afer surgery].

Thiamine effect on the blood 11-HOCS, hydrocortisone and corticosterone levels were studied in patients subjected to herniotomy and/or appendectomy under local anaesthesia. Intramuscular injections of thiamine in a dose of 0.12 g one day and 1.