Publications by authors named "Spaide R"
Purpose: To report the clinical characteristics of a newly defined entity, age-related choroidal atrophy.
Design: Retrospective, observational case series.
Methods: The choroidal thickness was measured in images obtained by positioning a spectral-domain optical coherence tomography device close enough to the eye to acquire an inverted image.
Purpose: To measure macular choroidal thickness in normal eyes at different points using enhanced depth imaging (EDI) optical coherence tomography (OCT) and to evaluate the association of choroidal thickness and age.
Design: Retrospective, observational case series.
Methods: EDI OCT images were obtained in patients without significant retinal or choroidal pathologic features.
Purpose: To describe the internal structure of pigment epithelial detachments (PEDs) seen in eyes with age-related macular degeneration (AMD) as imaged with enhanced depth imaging (EDI) spectral-domain optical coherence tomography (OCT).
Design: Retrospective observational case series.
Methods: The images were obtained by positioning a spectral-domain OCT device close enough to the eye to obtain an inverted image and 7 sections, each comprised of 100 averaged scans, were obtained within a 5 degrees x 15 degrees or larger rectangle to encompass the PED and accompanying neovascularization if present.
Objective: To describe cases of acute zonal occult outer retinopathy (AZOOR) in patients previously diagnosed as having multiple evanescent white dot syndrome (MEWDS).
Methods: In a retrospective case series, we studied fundus photographs, fundus autofluorescence images, optical coherence tomographic scans, fluorescein and indocyanine green angiograms, visual fields, and results of electroretinography.
Results: Three patients diagnosed as having MEWDS developed clinical, angiographic, autofluorescence, visual field, and/or electrophysiologic evidence of AZOOR.
Purpose: To describe a patient with birdshot retinochoroidopathy (BRC) with bilateral choroidal neovascularization (CNV) who was treated with intravitreal injection of bevacizumab and antiinflammatory medications.
Method: Interventional case report.
Patient: A 35-year-old woman with bilateral CNV associated with BRC.
Polypoidal choroidal vasculopathy in association with choroidal nevus.
Retin Cases Brief Rep
November 2014
Purpose: To report an association between polypoidal choroidal vasculopathy (PCV) and choroidal nevus in two patients.
Methods: Two patients with subretinal exudation associated with a choroidal nevus had a complete ophthalmologic examination, slit-lamp biomicroscopy, color fundus photography, fluorescein angiography (FA), and indocyanine green angiography (ICG).
Results: In the two eyes of the two patients with choroidal nevus, choroidal neovascularization with PCV-like characteristics was detected by ICG angiography.
Objective: To analyze the frequency of major age-related macular degeneration (AMD)-associated alleles in patients with multifocal choroiditis (MFC).
Methods: A cohort of 48 patients with MFC was compared with previously characterized cohorts of patients with advanced AMD (368 samples) and matched unaffected controls (368 samples). Allele and genotype frequencies of single nucleotide polymorphisms for the following AMD-associated alleles were evaluated: risk alleles in complement factor H (CFH) gene (Y402H and IVS14) and LOC387715/HTRA1 gene on 10q26 (A69S) and protective alleles in CFH (IVS1, IVS6, and delCFHR1-3) and complement factor B loci (H9L and R32Q).
Purpose: To evaluate intravitreal injection of ranibizumab as a potential treatment for decreased visual acuity (VA) secondary to central retinal vein occlusion (CRVO).
Design: Prospective, interventional case series.
Methods: Patients with CRVO prospectively recruited from a practice were administered intravitreal ranibizumab 0.
Spontaneous scleral rupture adjacent to retinochoroidal coloboma.
Retin Cases Brief Rep
November 2014
Background: Spontaneous scleral rupture in association with retinochoroidal coloboma is a rare and poorly understood event, with few reports in the literature.
Methods: Interventional case report.
Results: A 40-year-old man had a spontaneous decline in visual acuity with hypotony in the right eye.
Autofluorescence characteristics of congenital hypertrophy of the retinal pigment epithelium.
Retin Cases Brief Rep
November 2014
Purpose: To report the autofluorescence features of congenital hypertrophy of the retinal pigment epithelium (CHRPE).
Methods: Four patients with CHRPE were evaluated using autofluorescence in a camera-based system.
Results: All CHRPE lesions studied had well demarcated borders and were hypoautofluorescent.
Purpose: To examine the relationship between visual acuity and morphologic characteristics of macular holes as determined using spectral domain optical coherence tomography (SD OCT).
Methods: A retrospective analysis was performed of eyes with open and closed macular holes at a single, referral-based retina practice. The main outcome measures included best-corrected Snellen visual acuity and SD OCT findings, including the size of the macular hole and the disruption of the junction between inner segments (ISs) and outer segments (OSs) of the photoreceptors.
Purpose: To describe a method to obtain images of the choroid using conventional spectral-domain (SD) optical coherence tomography (OCT) and to evaluate choroidal thickness measurements using these images.
Design: Observational case series.
Methods: The images were obtained by positioning the SD OCT device close enough to the eye to obtain an inverted representation of the fundus in healthy volunteers who did not have pupillary dilation.
Objective: To report the results of intravitreous bevacizumab (Avastin) treatment for choroidal neovascularization (CNV) from causes other than age-related macular degeneration (AMD).
Methods: We performed a retrospective analysis of eyes that received intravitreous bevacizumab, 1.25 mg, for subfoveal non-AMD CNV at a referral-based retinal practice.
Purpose: : To determine safety and efficacy of intravitreal triamcinolone acetonide (IVTA) for refractory clinically significant diabetic macular edema (DME).
Design: : Prospective, randomized, dose-escalation pilot study comparing single injection of 2 mg versus 4 mg doses of IVTA.
Methods: : Inclusion criteria included clinically significant DME persisting >/=3 months after maximal laser treatment and visual acuity View Article and Find Full Text PDF
Purpose: To investigate the correlation between visual field (VF) defects in diseases of the acute zonal occult outer retinopathy (AZOOR)-complex and their spectral-domain optical coherence tomographic (OCT) findings.
Design: Observational case series.
Methods: Patients with AZOOR, multiple evanescent white dot syndrome (MEWDS), and multifocal choroiditis and panuveitis (MCP) examined in a private practice retinal referral center had threshold VF testing and spectral-domain OCT examination performed using a device capable of obtaining a block of 128 B-scans in a 6 x 6-mm region centered on the optic nerve and macula.
Purpose: To examine the ultrastructural correlates of spectral-domain optical coherence tomography (SD-OCT) findings in patients with vitreomacular traction (VMT).
Design: Observational case series.
Methods: Retrospective analysis of six eyes of consecutive patients who underwent vitrectomy surgery for VMT was performed in this single-center, noncomparative study.
Purpose: To investigate the characteristics of fundus autofluorescence in birdshot chorioretinopathy (BSCR).
Design: Retrospective, observational case series.
Participants: Sixteen eyes of 8 consecutive patients with BSCR (3 men, 5 women).
Purpose: To determine the incidence of endophthalmitis following intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents.
Design: A retrospective interventional case series.
Methods: A total of 10,254 intravitreal anti-VEGF injections (406 pegaptanib, 3,501 bevacizumab, and 6,347 ranibizumab) were performed from January 5, 2005 to October 18, 2007.
Purpose: To investigate the autofluorescence findings associated with multifocal choroiditis and panuveits (MCP), a condition that has marked potential to affect the retinal pigment epithelium (RPE).
Design: Observational case series.
Methods: This is a retrospective review of consecutive patients with MCP examined in a retinal referral practice.
Fundus autofluorescence (FAF) imaging is a novel imaging method that allows topographic mapping of lipofuscin distribution in the retinal pigment epithelium cell monolayer as well as of other fluorophores that may occur with disease in the outer retina and the subneurosensory space. Excessive accumulation of lipofuscin granules in the lysosomal compartment of retinal pigment epithelium cells represents a common downstream pathogenetic pathway in various hereditary and complex retinal diseases, including age-related macular degeneration. FAF imaging has been shown to be useful with regard to understanding of pathophysiologic mechanisms, diagnostics, phenotype-genotype correlation, identification of predictive markers for disease progression, and monitoring of novel therapies.
View Article and Find Full Text PDFPurpose: To delineate the 3-dimensional (3-D) relationship in vitreomacular traction (VMT) and idiopathic epiretinal membrane (ERM).
Design: Observational case series.
Methods: Forty-eight evaluable eyes of 35 patients with VMT or idiopathic ERM were investigated with spectral-domain (SD) optical coherence tomography (OCT).
Purpose: To review the pathophysiologic principles underlying increased autofluorescence from the outer retina and subretinal space using selected diseases as examples.
Methods: The ocular imaging information and histopathologic features, when known, were integrated for diseases causing increased autofluorescence from the outer retina and subretinal space. Inferences were taken from this information and used to create a classification scheme.