Publications by authors named "Soyoun Jung"

Article Synopsis
  • The Korean Breast Cancer Society (KBCS) has been collecting breast cancer data since 1996 to analyze clinical characteristics, with a focus on statistics from 2021.
  • In 2021, 34,628 women were diagnosed, predominantly in the 40-49 age group, with the majority having hormone receptor-positive, HER2-negative subtypes.
  • Despite a decline in breast cancer screenings during the COVID-19 pandemic, early-stage cases rose significantly, leading to improved overall survival rates thanks to better diagnoses and treatment advancements.
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This study aimed to elucidate the risk of developing breast cancer (BC) by reproductive and hormonal profiles to suggest risk-adapted starting screening ages and to investigate risks after negative mammography results to inform screening intervals in the Korean setting. Participants who performed health examinations between 2002 and 2023 at the National Cancer Center were analyzed. Risk-adapted starting age of screening was defined as the age at which women with various reproductive and hormonal profiles obtained a 10-year cumulative risk level similar to women aged 40 years in the general population.

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: Breast cancer is the most common cancer in women worldwide, requiring strategic efforts to reduce its mortality. This study aimed to develop a predictive classification model for breast cancer mortality using real-world data, including various clinical features. : A total of 11,286 patients with breast cancer from the National Cancer Center were included in this study.

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Early-onset breast cancer is known for its aggressive clinical characteristics and high prevalence in East Asian countries, but a comprehensive understanding of its molecular features is still lacking. In this study, we conducted a proteogenomic analysis of 126 treatment-naïve primary tumor tissues obtained from Korean patients with young breast cancer (YBC) aged ≤40 years. By integrating genomic, transcriptomic, and proteomic data, we identified five distinct functional subgroups that accurately represented the clinical characteristics and biological behaviors of patients with YBC.

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The BRCA1/2 pathogenic variant (PV) increases the risk of breast and ovarian cancer; thus, risk-reducing salpingo-oophorectomy (RRSO) and mastectomy (RRM) are recommended. We evaluated the effects of the graphical display of cancer risk compared with those of numerical presentation on the decision-making for risk-reducing (RR) surgery. A total of 471 women representing the Korean population were recruited.

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Purpose: The prognosis of microinvasive breast cancer (MIBC) is controversial, with a high reported rate of local recurrence (LR). This study aimed to evaluate the characteristics, treatments, and prognosis of patients with MIBC compared to those with carcinoma in situ (CIS) or early invasive cancer.

Methods: Patients who diagnosed with CIS or stage I breast cancer were retrospectively enrolled.

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Article Synopsis
  • A phase II trial was conducted to evaluate the effectiveness of combining letrozole (an endocrine therapy) with traditional chemotherapy in women with untreated stage II or III HR-positive, HER2-negative breast cancer.
  • Out of 53 patients, only 2 (4%) achieved a pathologic complete response (pCR), which was below the necessary threshold to continue the trial, though the overall response rate was high at 83%.
  • The treatment was deemed safe, with a 3-year disease-free survival rate of 87% and no deaths during treatment, but it did not significantly improve pCR rates, indicating the need for further research on neoadjuvant therapies for this cancer type.
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Purpose: This study evaluated the effectiveness of different surveillance intensities on morbidity and mortality in women with breast cancer.

Methods: This retrospective study included patients who had undergone breast cancer surgery in the Republic of Korea between 2009 and 2011. The patients were divided into two groups based on the intensity of their postsurgical surveillance: intensive surveillance group (ISG) and less-intensive surveillance group.

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Breast cancer (BrCa) remains a significant health concern globally, influenced by both nonmodifiable and modifiable risk factors. Limited studies have explored the role of color-specific vegetables and fruits, which are rich in specific phytonutrients, on BrCa risk. We hypothesized that consuming color-specific vegetables and fruits may decrease BrCa risk in Korean women.

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Article Synopsis
  • Current guidelines advise against routine imaging for asymptomatic breast cancer patients, yet advancements in treatments prompt a reevaluation of intensive imaging's role in survival outcomes.
  • A study of 4,130 patients from 11 Korean hospitals found that high-intensity imaging was linked to shorter distant metastasis-free survival, particularly for bone or lung metastases, while overall 5-year breast cancer-specific survival rates were high.
  • Despite earlier metastasis detection from frequent imaging, there was no significant correlation between screening intensity and breast cancer-specific survival, indicating that current treatments may diminish the benefits of intensive surveillance.
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  • Healthcare professionals (HCPs) need better training in genetic competency due to rising demand for genetic testing and counseling, particularly regarding hereditary cancer.
  • A systematic review of studies from 2013 to 2024 revealed that most HCPs, especially physicians, require practical counseling skills and specific knowledge tailored to their profession.
  • Key training topics identified include risk assessment, family communication, and information on risk-reducing strategies, highlighting the need for customized training programs in diverse cultural contexts.
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The association between dietary carotenoids and breast cancer (BC) risks were inconsistent. Therefore, this study investigated the association between dietary carotenoid and BC risks among Korean women. We recruited participants from the National Cancer Centre of Korea.

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Background: After neoadjuvant chemotherapy (NAC), the SLN identification rate is lower and has a higher false-negative rate than that at upfront surgery. This clinical trial aimed to confirm the effectiveness of sentinel lymph node (SLN) surgery by determining the lymph node identification rate using multimodal SLN marker methods in patients with advanced breast cancer undergoing NAC.

Patients And Methods: This clinical study is a prospective single-center randomized controlled trial involving patients with breast cancer receiving NAC.

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Article Synopsis
  • The Global Breast Cancer Initiative (GBCI), launched by WHO in 2023, focuses on improving early detection and management of breast cancer across 21 Asian countries.
  • A study investigated data availability for key performance indicators (KPIs) like stage at diagnosis and treatment completion by reviewing literature and national cancer reports.
  • Findings showed that only 57% of countries published relevant national cancer statistics, with significant differences from WHO estimates, and highlighted a strong link between early diagnosis, survival rates, and universal health coverage.
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Purpose: This study assessed health-related quality of life (HRQoL) of long-term breast cancer (BC) survivors diagnosed at early stages and compare with cancer-free, age-matched women.

Methods: The study population included BC survivors diagnosed with ductal carcinoma in situ (DCIS) or breast cancer stages I-II, who had undergone lumpectomy/mastectomy, with time since diagnosis ranging from 9 to 16 years. Survey was conducted at two tertiary hospitals in 2020.

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We aimed to examine the association between dietary isoflavone intake and the risk of breast cancer recurrence and summarize evidence on the role of dietary isoflavone intake in breast cancer prognosis. This prospective study included 592 breast cancer survivors who completed a dietary assessment. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models.

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Background: Nodal staging from sentinel lymph node (SLN) biopsy has become the standard procedure for early-stage breast cancer patients. SLN biopsy implementation after chemotherapy has previously been evaluated. This questionnaire study aimed to investigate the current trend of SLN biopsy after neoadjuvant chemotherapy (NAC) for locally advanced breast cancer.

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Article Synopsis
  • - This study investigated the outcomes of second primary breast cancer (SPBC) in women who previously had ovarian cancer, comparing it to primary breast cancer (PBC) in South Korea, analyzing 251,244 cases from 1999 to 2017.
  • - Results showed that patients with SPBC were older at diagnosis and received less adjuvant treatment compared to those with PBC, with survival rates significantly lower for SPBC (72.88% vs. 89.37%).
  • - The findings suggest SPBC occurs about 1.27 times more often in ovarian cancer survivors, indicating a need for proactive breast cancer screening in this group due to poorer survival outcomes correlated with older age and advanced stage.
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Oncotype DX (ODX), a 21-gene assay, predicts the recurrence risk in early breast cancer; however, it has high costs and long testing times. We aimed to identify clinicopathological factors that can predict the ODX risk group and serve as alternatives to the ODX test. This retrospective study included 547 estrogen receptor-positive, human epidermal growth factor receptor 2-negative, and lymph node-negative breast cancer patients who underwent ODX testing.

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Purpose: Li-Fraumeni syndrome (LFS) is a hereditary disorder caused by germline mutation in TP53. Owing to the rarity of LFS, data on its clinical features are limited. This study aimed to evaluate the clinical characteristics and prognosis of Korean patients with LFS.

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Background: Recent data from the ACOSOG Z0011 trial suggest that axillary lymph node dissection (ALND) may not be necessary for patients with positive sentinel lymph node biopsy (SLNB) receiving breast-conserving surgery (BCS) with irradiation. However, consensus statements and guidelines have recommended that patients undergoing mastectomy with tumor-positive sentinel node undergo completion ALND. In this study, we compared the locoregional recurrence rate of patients with tumor-positive sentinel nodes among three groups: mastectomy with SLNB, mastectomy with ALND and BCS with SLNB.

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Background: We have reported that serum progranulin (PGRN) levels are clinically significant in predicting recurrence in patients with HR-positive breast cancer. The aim of the present study was to examine whether PGRN levels might be associated with breast cancer mortality.

Methods: This was a cohort study of 695 newly diagnosed breast cancer patients who underwent curative surgery between 2001 and 2004.

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Article Synopsis
  • The study looked at how COVID-19 affected the diagnosis and treatment of breast cancer between January 2019 and February 2021.
  • It found that fewer breast cancer cases were diagnosed during the early part of the pandemic, but the numbers went back up later.
  • Overall, the type of breast cancer and the treatments used didn’t change much from before the pandemic to during it.
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