Test-Retest Reliability and Validity of TecnoBody D-Wall to Assess the Range of Motion During Overhead Squat in Healthy Individuals.

This study evaluated the validity and reliability of the TecnoBody D-Wall system in assessing joint range of motion (ROM) during overhead squat movements in healthy individuals, using Kinovea as a reference tool for data comparison. A total of 29 participants (16 males, 13 females) with a mean age of 28.41 ± 6.

Impact of the Abdominal Drawing-In Maneuver on Spinal Extensor Muscle Activity: A Randomized Controlled Double-Blind Trial Involving Individuals with Non-Specific Low Back Pain.

Non-specific low back pain (NSLBP) is a common musculoskeletal issue that can limit function and reduce the patient's quality of life. Enhancing spinal stabilizer muscle activity through targeted exercises may help improve spinal alignment and alleviate NSLBP symptoms. This study aimed to investigate whether incorporating the abdominal drawing-in maneuver (ADIM) into selected low back exercises influences the electromyographic (EMG) activity of key spinal extensor muscles.

Multidimensional analysis of serving speed in volleyball players by position, sets, and league types: interactions and statistical differences.

Purpose: Our study explores the multifaceted factors influencing serve speed in volleyball, including player position, match progression, and league level, providing actionable insights for performance optimization and injury prevention strategies.

Methods: Using a cross-sectional approach, the study analyzes 15.347 serves from various leagues.

Does Short Foot Exercise Combined with Breathing Exercise Increase Muscular Activity in Individuals with Pes Planus?

Background: Improvements in muscle oxygenation and exercise posture can significantly impact muscle contraction. The aim of this study was to compare the effects of combined breathing and exercise posture (sitting or standing) on the muscle activity of the foot and ankle during short foot exercises (SFE) in individuals with pes planus.

Methods: The study included 15 subjects aged 21.

Reliability and validity of new isokinetic strength assessment for rotator cuff muscles in a muscle architecture-based position.

Background/aim: Isokinetic strength assessment of the rotator cuff muscle is frequently applied in a variety of shoulder postures, but none of these consider muscular architecture, which is one of the most important aspects of improving strength development. This study aimed to examine the test and retest reliability and validity of the muscle architecture-based position (MABP), which is 25° abduction and 20° external rotation, in healthy subjects to be able to select a better isokinetic assessment position for shoulder rotator cuff muscles.

Materials And Methods: A total of 54 healthy males with a mean age of 21.

Reactivities of acrylamide warheads toward cysteine targets: a QM/ML approach to covalent inhibitor design.

Covalent inhibition offers many advantages over non-covalent inhibition, but covalent warhead reactivity must be carefully balanced to maintain potency while avoiding unwanted side effects. While warhead reactivities are commonly measured with assays, a computational model to predict warhead reactivities could be useful for several aspects of the covalent inhibitor design process. Studies have shown correlations between covalent warhead reactivities and quantum mechanic (QM) properties that describe important aspects of the covalent reaction mechanism.

Dissecting the Interaction Fingerprints and Binding Affinity of BYL719 Analogs Targeting PI3Kα.

Phosphatidylinositol-3-kinase Alpha (PI3Kα) is a lipid kinase which regulates signaling pathways involved in cell proliferation. Dysregulation of these pathways promotes several human cancers, pushing for the development of anticancer drugs to target PI3Kα. One such medicinal chemistry campaign at Novartis led to the discovery of BYL719 (Piqray, Alpelicib), a PI3Kα inhibitor approved by the FDA in 2019 for treatment of HR+/HER2-advanced breast cancer with a PIK3CA mutation.

Pathways from education and childhood parental death to successful aging: the role of social conditions and perceived income level.

Objectives: Although the association between adverse childhood conditions and health in later life has been relatively well established, little is known about how and through which mechanism this association develops. Building on the developmental adaptation model (Martin & Martin, 2002), the present study investigates the effects of distal and proximal influences on successful aging (SA).

Methods: A cross-sectional survey was conducted of 475 adults aged 50 and above (Mean age = 72.

Comparing event-related potentials of retrospective and prospective metacognitive judgments during episodic and semantic memory.

It is unclear whether metacognitive judgments are made on the basis of domain-generality or domain-specificity. In the current study, we compared both behavioral and event-related potential (ERP) correlates of retrospective (retrospective confidence judgments: RCJs), and prospective (feeling of knowing: FOK) metacognitive judgments during episodic and semantic memory tasks in 82 participants. Behavioral results indicated that FOK judgments reflect a domain-specific process, while RCJ reflect a domain-general process.

Testing a model of biopsychosocial successful aging based on socioemotional selectivity theory in the second half of life.

Objectives: We first tested a successful aging model, which included biomedical and psychosocial indicators. Next, we tested the assumptions on the social network characteristics of the socioemotional selectivity theory in a model where the outcome variable is successful aging.

Design: Cross-sectional study.

Predicting In Vivo Compound Brain Penetration Using Multi-task Graph Neural Networks.

Assessing whether compounds penetrate the brain can become critical in drug discovery, either to prevent adverse events or to reach the biological target. Generally, pre-clinical in vivo studies measuring the ratio of brain and blood concentrations () are required to estimate the brain penetration potential of a new drug entity. In this work, we developed machine learning models to predict in vivo compound brain penetration (as Log) from chemical structure.

Reliability and Validity of the Turkish Version of SF-12 Health Survey.

Objective: The aim of this study is to determine the psychometric properties of the Turkish version of the SF-12 Health - a widely used scale that assesses health - related quality of life - and to assess whether its psychometric properties are as good as with the 36 items long version (SF-36).

Method: The study included a total of 190 participants including 138 young adults aged from 18 to 29 years (22.04±2.

Effects of excessive violent video game playing on verbal memory: an event-related brain potentials study.

The goal of the study was to investigate temporal dynamics of excessive violent game playing. We compared behavioral data and event-related potentials (ERPs) of excessive video game players (EVGPs, n = 21) and non-players (NPs, n = 21) using a classical learning, cued recall and recognition paradigm, featuring violent and non-violent words. During the recognition phase, EVGPs performed better for violent words, but worse for non-violent words compared to NPs.

Investigating the role of attachment orientation during emotional face recognition: An event-related potential study.

We recorded event-related potentials (ERPs) while anxious and avoidant participants performed an emotional face recognition task featuring happy and angry faces. The avoidant attachment individuals were more accurate on angry trials, whereas anxious attachment individuals were more accurate on happy trials. FN400 amplitude was larger in the anxious attachment group than in the avoidant attachment group.

The Relationship Between Athletic Performance and Physiological Characteristics in Wheelchair Basketball Athletes.

: This study was aimed to investigate the relationship between athletic performance and physiological characteristics in wheelchair basketball (WB) athletes with different classification scores. : Twenty-six (24 male and 2 female) WB athletes were involved into the study. The participants were divided into two functional categories (Category A:1.

Comparing electrophysiological correlates of judgment of learning and feeling of knowing during face-name recognition.

We investigated the event-related potential (ERP) correlates of two metacognitive judgments, namely judgment of learning (JOL) and feeling of knowing (FOK) induced by a face-name recognition (FNR) task in 60 participants. The FNR produced N170 and P100 components at posterior, and an N100 component at anterior electrodes. Posterior P200, anterior N200 components were recorded during JOL and FOK judgments.

Neurobiological basis of feeling of knowing in episodic memory.

Feeling of knowing (FOK) is a metacognitive process which allows individuals to predict the likelihood that they will be able to remember, in the future, information which they currently cannot recall. Although FOK provides evidence for the mechanisms of metacognitive systems, the neurobiological basis of FOK is still unclear. We investigated the neural correlates of FOK induced by an episodic memory task in 77 younger adult participants.

Psychometric Properties of the Future Time Perspective Scale for the Turkish Population: Age Differences in Predictors of Time Perspective.

The purpose of this study was to determine the psychometric properties of the Turkish version of the Future Time Perspective Scale (FTPS-T) and examine age-group differences in the predictors of respondents' future time perspective. Data were collected from a sample of 202 young adults (aged 18-28 years) and 127 community-dwelling older adults (aged 60-86 years). The internal consistency and test-retest methods were employed to assess the reliability of the FTPS-T, and the FTPS-T's validity was assessed using construct- and criterion-related validity.

Assessment of psychosocial factors and distress in women having adjuvant endocrine therapy for breast cancer: the relationship among emotional distress and patient and treatment-related factors.

Purpose: The aims of this study were to comprehensively describe the psychosocial and medical characteristics of women who initiated tamoxifen or aromatase inhibitors for breast cancer and to compare levels of emotional distress according to their medical (tumor demographics, treatment type, treatment duration) and psychosocial (self-esteem, perceived social support, sociodemographic) characteristics.

Methods: A total of 104 women currently receiving tamoxifen or aromatase inhibitors was recruited from outpatient clinics and they were asked to complete self-report questionnaires including the Rosenberg Self-Esteem Scale, the Multidimensional Scale of Perceived Social Support and the Hospital Anxiety and Depression Scale during their routine follow-up. Psychosocial and medical characteristics of the patients were first described and subsequently the score of emotional distress was compared with these.

Patients' understanding of treatment goals and disease course and their relationship with optimism, hope, and quality of life: a preliminary study among advanced breast cancer outpatients before receiving palliative treatment.

Purpose: The aims of this study were to explore advanced breast cancer patients' knowledge of treatment intent and expectation of illness course and to evaluate their relationship with optimism, hope, and quality of life (QoL).

Methods: Patients with advanced breast cancer (n = 55) who were treated in the ambulatory clinic of the University of Hacettepe were included in the study. They completed Life Orientation Scale, The Hope Scale, and the European Organization for Research and Treatment of Cancer Quality of Life questionnaires.

Psychological distress and loneliness in caregiver of advanced oncological inpatients.

The objective of this study is to compare and examine the relationships between levels of loneliness, anxiety, depression, and other variables on primary caregivers and cancer inpatients. The study involved 100 Turkish primary caregivers of inpatients with advanced or terminal stages of cancer. Loneliness and anxiety scores were significantly higher for the primary caregivers of inpatients with terminal stage of cancer than primary caregivers of inpatients with advanced stage of cancer.

Effects of antidepressant treatments on polymorphonuclear elastase levels in patients with depression.

Background: We have previously reported that severe depression is associated with immunological and inflammatory alterations and these alterations may be showed easily by polymorphonuclear elastase (PMNE) measurements. The purpose of the present study is to show how PMN elastase levels change before and after antidepressant treatment.

Methods: Fifty-five patients with depression (40 with major depression [MD], 15 with dysthymic disorder [DD]) were included in the study.

Bipolar affective disorder associated with Klinefelter's syndrome--a case report.

Several cytogenetic surveys and literature reviews have suggested a possible association between Klinefelter's syndrome and bipolar illness. We describe a manic patient with Klinefelter's syndrome who was treated successfully with lithium. Our patient represents the 32nd reported case of bipolar disorder in an individual with a known chromosomal abnormality, the 15th with Klinefelter's syndrome, and the 11th with a karyotype of 47XXY.