Publications by authors named "Soykan Agar"

Article Synopsis
  • The study focuses on developing a new drug, "IHNOCS," aimed at treating Head, Neck, and Oral Cancer by targeting specific proteins to suppress cancer progression.
  • Using advanced computational tools, researchers demonstrated that IHNOCS effectively inhibits the KRTAP2-3 protein and modulates TGF-β, which helps to slow down cancer metastasis.
  • While the drug shows promising results in theory, it will need to go through further experimental testing, including lab studies and clinical trials, to evaluate its effectiveness in real-world situations.
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Introduction: Prostate cancer has emerged as a widespread health concern, with systemic inflammation believed to substantially contribute to its development and progression. The presence of systemic inflammatory responses has been established as an independent predictor of unfavorable long-term outcomes in prostate cancer patients. The goal of this study is to inhibit RXRα and RXRβ receptors, which are involved in prostate cancer, with Luteolin, Formononetin, and Kaempferol, with varying success.

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Article Synopsis
  • Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis due to its aggressive nature and limited treatment options, prompting research into new therapeutic targets, particularly Liver X receptors (LXRα and LXRβ).
  • Recent studies indicate that LXR ligands can inhibit cancer cell growth, with a focus on natural compounds like Baicalein, Beta-Sitosterol, and Polydatin for their potential effectiveness against PDAC.
  • Findings suggest Baicalein has significant inhibitory effects on both LXR receptors, while Beta-Sitosterol is particularly strong against LXRβ, indicating a need for further research to understand their mechanisms and therapeutic potential.
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In this study, experimental studies were carried out to explore the action mechanism of the anti-cancer drug Azacitidine on the double-stranded DNA (dsDNA). The drug binding constant (K) was found to be 4.13 ± 0.

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Eltrombopag is a powerful adjuvant anticancer drug used in treating MS (myelodysplastic syndrome) and AML (acute myeloid leukemia) diseases. In this study, the interaction mechanism between eltrombopag and DNA was studied by voltammetry, spectroscopic techniques, and viscosity measurements. We developed a DNA-based biosensor and nano-biosensor using reduced graphene oxide-modified glassy carbon electrode to detect DNA-eltrombopag binding.

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Pemetrexed is a well-known and widely used antineoplastic drug under the category of cytotoxic, folate anti-metabolites that is used in chemotherapeutic treatments, especially in malignant mesothelioma and non-small cell lung carcinoma. Here, the binding mechanism and interactions of Pemetrexed with double strain fish sperm deoxyribonucleic acid (dsDNA) were studied thoroughly both experimentally and theoretically, using multi-spectroscopic techniques and molecular docking simulations. Our ultimate goal is to understand better the potential of such antineoplastic drugs and, hence, to design drugs with high dsDNA binding affinities and fewer adverse effects.

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Fludarabine is a purine derivative, anti-neoplastic drug and is still being used in the treatments of chronic lymphocytic leukemia, small lymphocytic lymphoma, acute myeloid leukemia, Non-Hodgkin's lymphoma. It achieves its function by interacting with DNA. Therefore, the binding interactions of such drugs with deoxyribonucleic acid (DNA) is an important subject for pharmaceutical and biochemical studies aiming at designing better DNA binding drugs.

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