Publications by authors named "Sowon Bae"
Article Synopsis
- Transforming growth factor β (TGFβ) contributes to tumor immune evasion, especially in patients not responding to anti-PD-(L)1 treatments, and its effects are amplified by vascular endothelial growth factor (VEGF), making dual inhibition crucial for effective therapy.
- The study demonstrated that the compound TU2218 restores the function of immune cells like cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells while suppressing regulatory T cells, showing better results in mouse models compared to TGFβ inhibition alone.
- TU2218, when combined with anti-PD1 or anti-CTLA4 therapies, significantly increases antitumor effects and creates lasting immunological memory, suggesting its potential for enhancing
Background: Ovarian cancer is one of women's malignancies with the highest mortality among gynecological cancers. Paclitaxel is used in first-line ovarian cancer chemotherapy. Research on paclitaxel-resistant ovarian cancer holds significant clinical importance.
View Article and Find Full Text PDFOvarian cancer is the leading cause of death among gynecologic cancers. Paclitaxel is used as a standard first-line therapeutic agent for ovarian cancer. However, chemotherapeutic resistance and high recurrence rates are major obstacles to treating ovarian cancer.
View Article and Find Full Text PDFBackground: Melatonin, a neurohormone, maybe involved in physiological processes, such as antioxidation, anti-inflammation, and hair growth. In the present study, we investigated the effects of melatonin on proliferation and intracellular signaling in DP cells using a three-dimensional (3D) spheroid culture system that mimics the hair follicle system.
Methods: DP cells were incubated in monolayer (2D) and 3D spheroid culture systems.