No practical tests for vitamin B12 deficiency exist that are non-invasive and accessible, especially in rural areas, prompting examination of Karanth's test in a pilot study.
The study involved 83 patients at a tertiary teaching hospital and compared skin tone measurements to blood serum vitamin B12 levels, finding significant differences, particularly in patients with deficiencies.
Results indicated the Karanth's test has a sensitivity of 80% and specificity of 84.1%, suggesting it could be a valuable screening tool for vitamin B12 deficiency.