Publications by authors named "Sow O"

Article Synopsis
  • Acinetobacter baumannii, especially the carbapenem-resistant strains (CRAB), is a critical pathogen linked to antimicrobial resistance (AMR) and is prioritized by the WHO.
  • Phage therapy is being explored as a potential treatment for CRAB infections due to increasing resistance to conventional antibiotics.
  • A newly isolated lytic phage, vAbaIN10, exhibits effective lytic activity against CRAB in various conditions and shows promise in advancing treatment options for multidrug-resistant infections.
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Background and objectives Antimicrobial resistance (AMR) is a growing global threat, with carbapenemase-producing Enterobacterales (CPEs) representing a critical public health challenge. Rapid and accurate detection of CPEs is essential for controlling fatal bacterial AMR infections. This study evaluated the performance of MacConkey media supplemented with ertapenem (MacErt1 and MacErt2) for the detection of CPEs.

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This work evaluates a new prototype of a mobile wick solar still with a passive external condenser designed and manufactured by the company IPFH2O. The system's purpose is to distil non-potable water into potable water using solar energy. It is intended for populations in areas where access to drinking water remains difficult.

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Article Synopsis
  • Extended-spectrum β-lactamase-producing (ESBL-) bacteria are a major public health issue due to their widespread resistance to multiple antibiotics, particularly among broiler chickens in Dakar, Senegal.
  • A study found that 61.7% of broilers carried ESBL- in their cecum, with antibiotic tests revealing high resistance rates to various β-lactam antibiotics but full susceptibility to imipenem.
  • The research indicates significant multidrug resistance and the presence of multiple ESBL genes, highlighting the risk of human transmission through the food supply and the need for better surveillance and intervention strategies.
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Objective: To evaluate the prediction of esophageal varices by SEF measured by fibroscan® in cirrhotic patients followed at Cocody CHU.

Method: This was a cross-sectional study conducted at HGE at Cocody CHU for 5 years. Included records of compensated cirrhotics followed at HGE.

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Article Synopsis
  • * In this study, two bacteriophages, vAbBal23 and vAbAbd25, were isolated from wastewater in Dakar, Senegal, and extensively characterized for their effectiveness against extremely drug-resistant strains of A. baumannii.
  • * Both phages showed strong antibacterial properties across various pH levels and temperatures, with the ability to attack both active and biofilm forms of the bacteria, indicating their potential as safe therapeutic agents devoid of harmful genes.
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Introduction: Abdominal surgical emergencies have a high mortality rate. Effective management primarily relies on the early identification of patients at high risk of postoperative complications. The objective of our study was to determine the prognostic factors associated with poor outcomes from abdominal surgical emergencies in Senegal and to establish a predictive score for mortality for preoperative risk evaluation (NDAR (New Death Assessment Risk) score).

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Background: Schistosomiasis remains a public health concern worldwide. It is responsible for more than 240 million cases in 78 countries, 40 million of whom are women of childbearing age. In the Senegal River basin, both Schistosoma haematobium and Schistosoma mansoni are very prevalent in school-age children.

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Two bacteriophages (phages) of were isolated from sewage water collected from Dakar, Senegal. Phage vKpIN17 belongs to the genus within the family, with double-stranded DNA genomes, whereas vKpIN18 belongs to the genus of the family.

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Aim: To evaluate the epidemiological, etiological and evolutionary profile of vesico-vaginal fistulas (VVF) in university hospitals in Senegal.

Patients And Method: This is a retrospective, descriptive, single-center study, collecting the records of patients followed for VVF between January 2014 and December 2019 at the Urology and Andrology Department of the Centre hospitalier universitaire Aristide Le Dantec, Dakar, Senegal. The following parameters were studied: age, geographical origin, parity, and etiology of VVF.

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Access to palliative care, and more specifically the alleviation of avoidable physical and psychosocial suffering is increasingly recognized as a necessary component of humanitarian response. Palliative approaches to care can meet the needs of patients for whom curative treatment may not be the aim, not just at the very end of life but alleviation of suffering more broadly. In the past several years many organizations and sectoral initiatives have taken steps to develop guidance and policies to support integration of palliative care.

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Background: Adherence to tuberculosis preventive treatment (TPT) is an important determinant of clinical benefit. We assessed the association of participant behaviors early in TPT with subsequent discontinuation.

Methods: We used data from a phase 3 randomized trial and the preceding phase 2 trial to compare 4 months of rifampin to 9 months of isoniazid for TPT.

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Purpose: To realize a systematic review to evaluate groin hernia surgery for adults in sub-Saharan Africa.

Methods: We conducted a systematic review and meta-analysis, the primary objective of which was to determine the surgical techniques used for unilateral groin hernia surgery in sub-Saharan Africa. Studies published in the last 20 years were considered.

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The kidney's primary squamous cell carcinoma is a rare tumor, representing 0.5-0.8% of malignant renal tumors and 4% of upper urinary tract tumors.

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Colonic pseudotumors secondary to fishbone perforation are rare and not easily diagnosed, as the clinical presentation is often misleading. We report the case of a 61-year-old man patient with no medicalhistory, whose clinical picture was in favor of a colonic tumor. The diagnosis of colonic perforation by fishbone was not possible preoperatively due to lack of CT scan.

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Circumcision is one of the most commonly performed surgical procedures. As traditional ritual circumcisions are still practiced in the community, in Senegal the majority of circumcisions are performed in hospitals. We report the case of a 9-year-old boy who underwent a total amputation of the glans after a circumcision in a pharmacy by an unqualified agent.

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Heat pump systems can simultaneously produce cooling energy for space cooling in hotels, office and residential buildings and heat for desalination using membrane distillation (MD). The MD technique uses a heat input at a temperature compatible with the levels of heat pump condensers (<60 °C). A heat pump prototype coupled with an air-gap membrane distillation unit was constructed and tested.

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Bladder diverticulum represents a herniation of the bladder mucosa and submucosa through a point of weakness in the detrusor muscle. Bladder diverticula are rare and most often described in men. We report a symptomatic giant bladder diverticulum in a 56-year-old postmenopausal woman.

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Primary rhabdomyosarcoma of the adult prostate is rare and associated with an aggressive clinical course. Combined modality therapy has resulted in marked improvement in survival rates and reduced surgical morbidity for children with these tumors. However, in adults the prognosis remains poor.

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Illegally induced abortions remain a significant public health issue in developing countries. We report a case that was complicated by a vesicovaginal fistula with intravesical calcification of the piece of wood used to perform the illegal abortion. A -vesical approach allowed extraction of the calcified foreign body and closure of the vesicovaginal fistula.

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The purpose of this study was to assess outcomes of radical prostatectomy in patients with prostate cancer. We conducted a retrospective single-center study in the Department of Urology and Andrology at the Aristide Le Dantec Hospital in Dakar from June 1, 2010 to May 31, 2016. We collected data of 60 patients undergoing radical retropubic prostatectomy associated with dissection of the iliac and obturator nodes.

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Aim: to evaluate the results of two-level urethroplasty in the treatment of complex urethral strictures in our clinical center.

Patients And Method: Thiswas a retrospective cross sectional study from January 2012 to September 2015 in our clinical center. Patients operated according to Bengt Johanson technique were included.

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Background: The 2013-16 Ebola virus disease epidemic in west Africa caused international alarm due to its rapid and extensive spread resulting in a significant death toll and social unrest within the affected region. The large number of cases provided an opportunity to study the long-term kinetics of Zaire ebolavirus-specific immune response of survivors in addition to known contacts of those infected with the virus.

Methods: In this observational cohort study, we worked with leaders of Ebola virus disease survivor associations in two regions of Guinea, Guéckédou and Coyah, to recruit survivors of Ebola virus disease, contacts from households of individuals known to have had Ebola virus disease, and individuals who were not knowingly associated with infected individuals or had not had Ebola virus disease symptoms to serve as negative controls.

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Background: Most countries in Subsaharan Africa have well-established National Tuberculosis Control Programs with relatively stable routine performances. However, major epidemiological events may result in significant disruptions. In March 2014, the World Health Organization announced the outbreak of Ebola virus disease in Guinea, a country with a high incidence of TB and HIV.

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Background: Despite the predictive role of body weight variation in treatment outcome in multidrug-resistant tuberculosis (MDR-TB), few corroborating data are available. We studied weight variation in patients with MDR-TB to identify groups of weight change and to determine factors that influence these changes.

Methods: We analyzed patients with rifampicin resistance who were treated with an MDR-TB treatment regimen between June 07, 2016 and June 22, 2018 at three major drug-resistant TB centers in Guinea.

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