Complete blood count and systemic inflammation indices in individuals with Alzheimer's disease: A case-control study.

Alzheimer's disease (AD) is the most common cause of dementia, characterized by progressive cognitive and functional decline and is associated with aging. Chronic inflammatory processes are also involved in its the etiology, as the consequence or cause of proteinopathy (amyloid and tau load in the brain). This study aimed to investigate the complete blood count and systemic inflammation indices in 61 individuals with AD, compared to 59 cognitively healthy individuals as controls.

Effect of exogenous treatment with zaxinone and its mimics on rice root microbiota across different growth stages.

Enhancing crops productivity to ensure food security is one of the major challenges encountering agriculture today. A promising solution is the use of biostimulants, which encompass molecules that enhance plant fitness, growth, and productivity. The regulatory metabolite zaxinone and its mimics (MiZax3 and MiZax5) showed promising results in improving the growth and yield of several crops.

Floral developmental insights into two species of Erythrina (Fabaceae: Papilionoideae: Phaseoleae) pollinated by hummingbirds and passerines.

Erythrina is a Pantropical bird-pollinated genus of Fabaceae. Thus, its flowers are usually large, showy, red or yellowish, offering nectar as the principal resource. There are two main interaction systems with birds in Erythrina: in one, the inflorescences are erect and the flowers are horizontal, offering no landing platform; in the other, the inflorescences are horizontal and the flower parts are more exposed.

Endocrine-disrupting chemical, methylparaben, in environmentally relevant exposure promotes hazardous effects on the hypothalamus-pituitary-thyroid axis.

Methylparaben (MP) belongs to the paraben class and is widely used as a preservative in personal care products, medicines, and some foods. MP acts as an endocrine disrupting chemical (EDC) on the hypothalamic-pituitary-thyroid (HPT) axis. However, the effects of MP have not yet been completely elucidated, as published results are scarce and controversial.

Embryonic dormancy in Aedes aegypti and Aedes albopictus (Diptera: Culicidae): a survival and dispersal mechanism.

Aedes aegypti and Aedes albopictus are the main vectors of arboviruses such as dengue, Zika virus, and chikungunya. Ae. aegypti is a widely spread mosquito in tropical and subtropical regions, whereas Ae.

Intranasal influenza-vectored vaccine expressing pneumococcal surface protein A protects against Influenza and Streptococcus pneumoniae infections.

Streptococcus pneumoniae and influenza A virus (IAV) are significant agents of pneumonia cases and severe respiratory infections globally. Secondary bacterial infections, particularly by Streptococcus pneumoniae, are common in IAV-infected individuals, leading to critical outcomes. Despite reducing mortality, pneumococcal vaccines have high production costs and are serotype specific.

Soil pH modulates activity of low-affinity methane oxidation in soils from Amazon region.

Aims: In the Amazon region, pastures are the main land use subsequent to deforestation and this change can result in soil acidification and degradation. Liming is a management practice to increase soil pH, important to recover degraded lands and increase soil fertility, but its impacts on soil methane cycling in tropical soils is unknown. Here we investigate the role of soil pH on methane uptake under high concentrations of the gas, manipulating pasture and forest soils pH by liming and evaluating the active methane cycling microbial community.

A comprehensive study on MDP effects: Microshear bond strength and fatigue resistance in 4YSZ ceramics.

The aim of this study is to assess the presence of MDP at various stages of the bonding procedure, enhance the adhesive and mechanical behavior of cemented zirconia ceramics. Fifty ceramic slices (15 × 15 × 2 mm) and 48 discs (Ø= 10 mm, 1 mm thickness) were prepared, sintered, air-abraded with aluminum oxide, and allocated considering: 1) microshear bond strength (µSBS) between ceramic slices and luting agent cylinders (height= 1 mm, Ø= 1.2 mm); 2) fatigue behavior, ceramic discs paired and bonded onto fiber-epoxy resin discs (Ø= 10 mm, 2.

Kidney transplant outcomes of Māori and Pasifika people receiving transplantation in Australia: an Australia and New Zealand Dialysis and Transplant Registry study.

Background: The numbers of Māori and Pasifika peoples with kidney failure living in Australia are rising. However, data describing outcomes of those proceeding to transplantation are limited. This study describes clinical outcomes of Māori and Pasifika peoples who received a kidney transplant in Australia.

Saint Paul, the Apostle, and the Gastaut-Geschwind syndrome.

The interface between epilepsy and religiosity has been a long-standing matter of debate. Epilepsy has affected several religious leaders throughout history. Hyperreligiosity may be observed in patients with temporal lobe epilepsy as a component of the so-called Gastaut-Geschwind syndrome which involves other behavioral and personality traits such as hyposexuality, viscosity, philosophical concerns, sense of personal destiny, hypergraphy, emotionality, and irritability.

Macrofouling on marine litter in a Southwest Atlantic urban tropical bay and surrounds.

Rafting is the transport of marine litter by organisms, influenced by substrate characteristics such as degradation, shape, surface orientation, color, and polymer type. This study focuses on rafting in the Southwest Atlantic, characterizing biofouling on different materials across high- and low-energy beaches. Conducted in Guanabara Bay and Niteroi's oceanic beaches, sampling focused on strandlines.

Rehabilitation of back pain with laser associated with negative or positive pressure massage in workers: A randomized controlled trial.

Background And Purpose: Work-related musculoskeletal disorders (WMSDs) are an array of conditions affecting the human locomotor system, such as muscles, tendons, nerves, bones, and joints. It is related to physiological, kinesiological and biomechanical changes which result in pain, paresthesia, inflammation, weakness, tiredness, heaviness in limbs, fatigue, reduced range of motion and/or compression of peripheral nerves. The aim of this study was to investigate the therapeutic effects of positive (massage gum) or negative pressure (vacuum therapy) combined with laser on the health of workers with back pain, investigating pain intensity, shoulder mobility, spinal flexibility, life quality, and well-being.

Effect of curcumin and three analogues on pre-osteoblast cells' viability, differentiation, and gene expression.

Curcumin, found in turmeric rhizomes (Curcuma longa L.), has been widely studied for its potential health benefits, including anti-inflammatory, antioxidant, and wound-healing properties. However, due to its low bioavailability and unfavorable pharmacokinetics, analogous compounds have been developed to obtain better biopharmaceutical characteristics and enhanced biological effects.

Breaking boundaries: A systematic review of the application of non-invasive brain stimulation symptoms and sleep parameters in people with ADHD.

Background: Studies of non-invasive treatments such as repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) can contribute in an alternative way to the symptoms treatment and changes in sleep patterns in attention deficit hyperactivity disorder (ADHD), due to some scientific evidence of action on cognition and clinical characteristics.

Aim: The aim of this systematic review was to evaluate studies of non-invasive brain stimulation using rTMS and tDCS on symptoms and sleep parameters in people with ADHD, in order to synthesize the main findings on intervention effects.

Methodology: A systematic review was carried out using the PRISMA protocol in the PubMed/Medline, Embase, PsycInfo, CINAHL, PEDro and Central-Cochrane library databases were initially carried out on 14 March 2024 and repeated until September 2024.

Taxonomic review of Aclis Lóven, 1846 (Gastropoda, Eulimidae) from Brazil with notes on other congeners from the western Atlantic and Saint Helena.

A taxonomic review of Aclis Lóven, 1846 from Brazil led to the discovery of ten species, five of them are new. Before this study, only four species were known from the area. Aclis sarissa Watson, 1881 is revised and reassessed regarding its shell variability.

Shearless and periodic attractors in the dissipative Labyrinthic map.

The Labyrinthic map is a two-dimensional area-preserving map that features a robust transport barrier known as the shearless curve. In this study, we explore a dissipative version of this map, examining how dissipation affects the shearless curve and leads to the emergence of quasi-periodic or chaotic attractors, referred to as shearless attractors. We present a route to chaos of the shearless attractor known as the Curry-Yorke route.

Effect of the reduction in the exposure time to at-home bleaching gel on color change and tooth sensitivity: A systematic review and meta-analysis.

Objective: To investigate the effect of reducing exposure time to at-home bleaching gel on color change and tooth sensitivity.

Materials And Methods: The search was carried out using PubMed, Scopus, Web of Science, EMBASE, LILACS, Cochrane. Randomized clinical trials (RCTs) were included involving adult patients who have never undergone bleaching treatment before (P), subjected to bleaching with a reduced exposure time to the at-home bleaching agent (I) compared to those who used it for the time indicated by the manufacturer (C), to evaluate the effects on color change and tooth sensitivity (O).

Bee pollen from bracatinga (Mimosa scabrella): Effects of gastrointestinal digestion and epithelial transport in vitro on phenolic profile and bioactivities.

The main objective of the present work was to assess the phenolic profile of bracatinga (Mimosa scabrella) bee pollen, and its antioxidant and anti-inflammatory activities after gastrointestinal digestion in vitro and epithelial transport in a Caco-2 cell monolayer model. The botanical origin of bee pollen was confirmed by optical microscopy and scanning electron microscopy. As major results, 34 phenolic compounds (13 phenylamides, 14 flavonols, and 7 flavanones) were tentatively identified in the extract of bracatinga bee pollen by HPLC-ESI-QTOF-MS.

In Vitro Antitumor and Antimetastatic Activity of a New Lapachol Derivative against Metastatic Breast Carcinoma.

Objective: Breast cancer represents the most prevalent type of tumor throughout the world. Considering the side effects caused by the available treatments, the resistance acquired by cells to cytotoxic agents, and metastasis, it is necessary to search for new sources of antitumor and antimetastatic therapies. Given the numerous antitumor studies involving the synthesis of substances derived from the naphthoquinone lapachol, we investigated the antineoplastic potential of a new synthetic substance (APO-3) derived from lapachol, alone and in combination with the chemotherapeutic agent paclitaxel (PTX), against 4T1 cells, a murine breast cancer cell line.

Evaluation of safety and efficacy of Brazilian brown propolis from . in preventing colon cancer.

Brazilian propolis produced by honeybees have been widely studied, but few data exist regarding the safety and pharmacological potential of this natural product. The aim of the present study was to examine the toxicity, genotoxicity, and chemoprevention effects attributed to exposure to the brown propolis hydroalcoholic extract (BPHE) of . Acute oral toxicity test was conducted using Wistar Hannover rats, demonstrating that the highest dose tested (2,000 mg/kg b.