Background: Preeclampsia is a major hypertensive disorder of pregnancy, which may lead to severe complications, particularly in the first two weeks of the postpartum period. During the postpartum period, blood pressure levels remain high, often increasing to levels higher than those experienced during pregnancy. Furosemide, a fast-acting diuretic, reduces the intravascular volume overload and may represent an alternative to accelerate the normalization of blood pressure levels.
View Article and Find Full Text PDFIntroduction: Antimicrobial resistance (AMR) is a major public health challenge globally. This study aimed to analyze the antibacterial consumption (ATBc), and the incidence of multidrug-resistant organisms (MDRO), focusing on pathogens Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. (ESKAPE group), in a Brazilian tertiary care hospital.
View Article and Find Full Text PDFDengue fever, caused by the dengue virus (DENV), poses a significant global health challenge, particularly in tropical and subtropical regions. Recent increases in indigenous DENV cases in Europe are concerning, reflecting rising incidence linked to climate change and the spread of mosquitoes. These vectors thrive under environmental conditions like temperature and humidity, which are increasingly influenced by climate change.
View Article and Find Full Text PDFThis study investigates the structural and biophysical properties of the wild-type antimicrobial peptide LyeTx I, isolated from the venom of the spider , and its analog LyeTx I-b, designed to enhance antibacterial activity, selectivity, and membrane interactions by the acetylation and increased amphipathicty. : To understand the mechanisms behind these enhanced properties, comparative analyses of the structural, topological, biophysical, and thermodynamic aspects of the interactions between each peptide and phospholipid bilayers were evaluated. Both peptides were isotopically labeled with H-Ala and N-Leu to facilitate structural studies via NMR spectroscopy.
View Article and Find Full Text PDFBackground: In this competitive world, students undergo various scholastic stress and mental health issues. The scholastic stress has a great impact on students' life and results in the prevalence of several psychological consequences such as stress-related disorders, anxiety, depression, and nervousness, which disturb their academic performances. Therefore, the present study was conducted to assess academic stress, perceived parental pressure, and anxiety related to competitive entrance examinations and the general well-being among adolescents.
View Article and Find Full Text PDFJ Venom Anim Toxins Incl Trop Dis
January 2025
Background: This study examines the impact of Phα1β, a spider peptide derived from the venom of , on the Kv11.1 potassium channel in HEK293 cells transfected with the human ERG potassium channel. Phα1β inhibits high-voltage calcium channels and acts as an antagonist of the TRPA1 receptor, both of which play crucial roles in pain transduction pathways.
View Article and Find Full Text PDFAim: Consensus is lacking regarding the management of extramesorectal lymph nodes (EMLN) in rectal cancer. Using simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT), we targeted involved EMLN and reserved lateral pelvic lymph nodal dissection (LPLND) for nonresponders. The primary aim of this work was to determine the proportion of patients who avoided LPLND and to establish the pathological EMLN positivity rate.
View Article and Find Full Text PDFEu-Gd co-doped glasses composed of 15BO-12SiO-(40-x)TeO-3EuO-xGdO-12BiO-8BaO-10ZnO with x = 0-4 mol% (coded as EuGd-x) were fabricated using melt quench approach to develop transparent radiation shielding system. Their structural, optical and mechanical properties were examined. 5.
View Article and Find Full Text PDFObjective: To establish a reference interval for amino acid profiles for healthy red wolves (Canis rufus).
Methods: Heparinized plasma of 48 red wolves was collected between August 2023 and April 2024 and sent to the University of California-Davis Amino Acid Laboratory for analysis. Reference intervals were created using the published American Society for Veterinary Clinical Pathology reference interval guidelines.
Biomed Mater
January 2025
Innovative skin dressings are needed for an effective skin wound treatment. Here in, it was used spongin-like collagen (SC) from marine sponge Chondrilla caribensis as a promising biomaterial, sodium alginate as matrix and, 3D printing technique to manufacture skin dressings in three concentrations (C1, C2, C3). The physicochemical, morphological and biological (in vitro) results were investigated.
View Article and Find Full Text PDFJ Med Case Rep
January 2025
Introduction: Severe acute respiratory syndrome coronavirus infection is responsible for multisystemic disease and has high transmissibility. It culminated in a pandemic, challenging scientific knowledge and care capacity. Neurological symptoms are highly prevalent, and cases of encephalitis have been described, in both peri- and postinfectious periods.
View Article and Find Full Text PDFPurpose: Corneal dysmorphologies (CDs) are typically classified as either regressive degenerative corneal dystrophies (CDtrs) or defective growth and differentiation-driven corneal dysplasias (CDyps). Both eye disorders have multifactorial etiologies. While previous work has elucidated many aspects of CDs, such as presenting symptoms, epidemiology, and pathophysiology, the genetic mechanisms remain incompletely understood.
View Article and Find Full Text PDFThe pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in over 7 million global fatalities and billions of individuals diagnosed with COVID-19. Acute and chronic muscle impairment associated with SARS-CoV-2 infection affected a substantial number of patients, leading to the development of symptoms such as fatigue, muscle pain, and exercise intolerance. Our study introduces an animal model to improve understanding of the pathogenicity caused by SARS-CoV-2 in human skeletal muscle.
View Article and Find Full Text PDFCellulose, the most abundant biopolymer on Earth, is biodegradable, nontoxic, and derived from renewable sources. Its properties and applications depend on the extraction methods and sources, making plant waste reuse a sustainable production option. This study aimed to assess the potential of cowpea pod skin () as a source of microcellulose (CPMC) using a chemical-mechanical process involving ball milling combined with acid hydrolysis.
View Article and Find Full Text PDFBackground And Aims: Skeletal muscle (SM) fat infiltration, or intermuscular adipose tissue (IMAT), reflects muscle quality and is associated with inflammation, a key determinant in cardiometabolic disease. Coronary flow reserve (CFR), a marker of coronary microvascular dysfunction (CMD), is independently associated with body mass index (BMI), inflammation and risk of heart failure, myocardial infarction, and death. The relationship between SM quality, CMD, and cardiovascular outcomes is not known.
View Article and Find Full Text PDFUnlabelled: To evaluate the accuracy of the lung ultrasound score (LUS) in predicting ventilatory weaning failure during neonatal hospitalization in the NICU and to identify factors associated with weaning failure, including corrected gestational age (CGA). This prospective, longitudinal, pragmatic and observational cohort study included neonates on mechanical ventilation for at least 48 h. The primary outcome was the accuracy of lung ultrasound in predicting 3-day weaning failure, with the ROC curve used to determine the best LUS cutoff (sensitivity and specificity).
View Article and Find Full Text PDFObjective: Adolescence marks a time of transition where teenagers are learning to advocate for themselves. In those with underlying chronic conditions such as adolescent dysautonomia, improving communication between clinic visits may improve connection with their health care provider which may aide management. Our aims were as follows: (1) to implement a text message platform to increase communication between adolescent patients and health care provider (HCP); (2) to evaluate its effect on quality of life (QoL), symptom burden, and patient engagement; and (3) to determine patient satisfaction with the platform.
View Article and Find Full Text PDFObjective: To analyze the factors associated with the hygienic-sanitary quality of donated human milk in terms of the donor profile and pumping site.
Method: Cross-sectional study with retrospective data collection of records of human milk samples donated to a Human Milk Bank in São Paulo, Brazil, from 2014 to 2019. Characteristics of human milk donors, pumping site, and hygienic-sanitary quality were analyzed based on the Standards of the Brazilian Human Milk Bank Network.
Epidemiol Serv Saude
January 2025
Objective: To estimate vaccination coverage and analyze factors associated with full vaccination among children up to 15 months old in the city of Natal-RN, Brazil.
Methods: Population-based survey with data recorded on children's vaccination cards and interviews conducted in 2020 and 2021. Analysis of factors associated with complete vaccination was performed by calculating prevalence ratios (PR) and 95% confidence intervals (95%CI) using Poisson regression.
Functional diversity (FD) reflects within- and between-site variation of species traits (α- and β-FD, respectively). Understanding how much data types (occurrence-based vs. abundance-weighted) and spatial scales (sites vs.
View Article and Find Full Text PDFObjective: To describe the Brazilian experience of responding to public health emergencies in 2023, the organizational structure, and epidemiological characteristics.
Methods: Three emergencies (case studies) that occurred during the study year were analyzed according to the actions implemented during the response and the impacts on the population. The public health emergencies were summarized and analyzed through research on official documents and websites of the Ministry of Health and local health authorities.
Visual working memory and verbal storage are often investigated independently of one another. However, a growing body of evidence suggests that naming visual stimuli can provide an advantage in performance during visual working memory tasks. On the other hand, there is also evidence that labeling could lead to biases in recall.
View Article and Find Full Text PDFFish Shellfish Immunol
February 2025
The study aimed to assess the impact of dietary supplementation with tannic acid on the growth, health, and survival of Oreochromis niloticus following exposure to Aeromonas hydrophila. A total of 320 fish were divided into 16 tanks and assigned to four treatment groups: feed with 0.2 % tannic acid (TA), 0.
View Article and Find Full Text PDFThis paper highlights the complexity and urgency of addressing plastic pollution, drawing attention to the environmental challenges posed by improperly discarded plastics. Petroleum-based plastic polymers, with their remarkable range of physical properties, have revolutionized industries worldwide. Their versatility-from flexible to rigid and hydrophilic to hydrophobic-has fueled an ever-growing demand.
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