Identification of candidate genes determining chemosensitivity to anti-cancer drugs of gastric cancer cell lines.

In order to efficiently develop improved cancer therapies it is important to predict the efficacy of anti-cancer drugs. In this regard, identification of genes that are related to drug sensitivity is vital. We previously established a panel of 39 human cancer cell lines (JFCR39) and a panel aiming for organ-specific analysis of 45 human cancer cell lines (JFCR45).

Evaluation of action mechanisms of toxic chemicals using JFCR39, a panel of human cancer cell lines.

We previously established a panel of human cancer cell lines, JFCR39, coupled to an anticancer drug activity database; this panel is comparable with the NCI60 panel developed by the National Cancer Institute. The JFCR39 system can be used to predict the molecular targets or evaluate the action mechanisms of the test compounds by comparing their cell growth inhibition profiles (i.e.