Publications by authors named "Sousuke Hashida"
Article Synopsis
- The study compares the oncological outcomes of sentinel lymph node biopsy (SNB) and pelvic lymphadenectomy (PLD) in patients with early-stage cervical cancer.
- A total of 104 patients, with tumor sizes mainly ≤2 cm, underwent laparoscopic or robot-assisted radical hysterectomy, showing that only one patient in the SNB group had lymph node metastasis compared to nine in the PLD group.
- Follow-up results indicated a 100% disease-free survival (DFS) rate for the SNB group and a 91.5% rate for the PLD group, suggesting that SNB is adequate for patients with smaller tumors, potentially making PLD unnecessary.
: The application of personalized cancer treatment based on genetic information and surgical samples has begun in the field of cancer medicine. However, a biopsy may be painful for patients with advanced diseases that do not qualify for surgical resection. Patient-derived xenografts (PDXs) are cancer models in which patient samples are transplanted into immunodeficient mice.
View Article and Find Full Text PDFPatient-derived xenograft (PDX) models retain the characteristics of tumors and are useful tools for personalized therapy and translational research. In this study, we aimed to establish PDX models for uterine corpus malignancies (UC-PDX) and analyze their similarities. Tissue fragments obtained from 92 patients with uterine corpus malignancies were transplanted subcutaneously into immunodeficient mice.
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- This study compares lymphatic complications in patients with endometrial cancer who underwent sentinel node biopsy (SNB) versus pelvic lymphadenectomy (LND) from September 2012 to April 2022.
- Out of 388 patients, those who had SNB experienced significantly lower rates of lower-extremity lymphedema (LEL) at 2.0% compared to 21.3% in the pelvic LND group.
- Additionally, no patients in the SNB group developed pelvic lymphocele (PL), while 2.1% of the pelvic LND group did, highlighting SNB's lower risk for lymphatic complications overall.
Article Synopsis
- * This study focuses on identifying cancer-specific miRNAs in extracellular vesicles (Te-EVs) collected from patients with OCC, comparing them to normal ovarian tissue.
- * The research found 37 miRNAs significantly elevated in OCC tissue, with 6 showing decreased levels post-surgery, suggesting these miRNAs could serve as promising biomarkers for early OCC diagnosis.
Background: The sentinel lymph node (SLN) procedures using indocyanine green (ICG) have recently been performed worldwide. The aim of this study was to emphasise the safety of robot-assisted modified radical hysterectomy (RAMRH) with removal of the lymphatic vessels (RLV) using ICG in endometrial cancer according to a single surgeon's experience.
Methods: Robot-assisted modified radical hysterectomy with RLV using ICG was performed in patients with endometrial cancer.
Patient-derived xenograft (PDX) models are useful tools for preclinical drug evaluation, biomarker identification, and personalized medicine strategies, and can be developed by the heterotopic or orthotopic grafting of surgically resected tumors into immunodeficient mice. We report the PDX models of cervical cancer and demonstrate the similarities among original and different generations of PDX tumors. Fresh tumor tissues collected from 22 patients with primary cervical cancer were engrafted subcutaneously into NOD.
View Article and Find Full Text PDFBackground: Because patient-derived xenograft (PDX) models resemble the original tumors, they can be used as platforms to find target agents for precision medicine and to study characteristics of tumor biology such as clonal evolution and microenvironment interactions. The aim of this review was to identify articles on endometrial cancer PDXs (EC-PDXs) and verify the methodology and outcomes.
Methods: We used PubMed to research and identify articles on EC-PDX.
Article Synopsis
- A recent study indicated that minimally invasive surgery (MIS) for cervical cancer might lead to higher recurrence and death rates compared to abdominal radical hysterectomy (ARH).
- The current research compared outcomes for 182 patients with early-stage cervical cancer who underwent either MIS using vaginal closure or ARH, focusing on disease-free survival (DFS) and overall survival (OS).
- Results showed minimal differences in recurrence rates (4.5% for MIS vs. 3.5% for ARH) and similar DFS and OS across both groups, suggesting that MIS with vaginal closure does not significantly increase risks for these patients.
Background: Patient-derived xenograft (PDX) models have been a focus of attention because they closely resemble the tumor features of patients and retain the molecular and histological features of diseases. They are promising tools for translational research. In the current systematic review, we identify publications on PDX models of cervical cancer (CC-PDX) with descriptions of main methodological characteristics and outcomes to identify the most suitable method for CC-PDX.
View Article and Find Full Text PDFPyometra usually develops in elderly women, and it can be caused by various etiologies. We describe a rare case of pyometra with a colouterine fistula due to rectal cancer presenting as acute abdomen. A 67-year-old woman with purulent vaginal discharge and abdominal distension was referred to our hospital for suspected pyometra.
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