Publications by authors named "Sourish Bandyopadhyay"

Background: Although lobar patterns of emphysema heterogeneity are indicative of optimal target sites for lung volume reduction (LVR) strategies, the presence of segmental, or sublobar, heterogeneity is often underappreciated.

Objective: The aim of this study was to understand lobar and segmental patterns of emphysema heterogeneity, which may more precisely indicate optimal target sites for LVR procedures.

Methods: Patterns of emphysema heterogeneity were evaluated in a representative cohort of 150 severe (GOLD stage III/IV) chronic obstructive pulmonary disease (COPD) patients from the COPDGene study.

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Article Synopsis
  • Emphysema often affects the lungs unevenly, making it crucial for lung volume reduction therapies to target the most damaged areas while sparing healthier regions.
  • Identification of emphysema severity can be performed through various quantification methods, with the tissue/air ratio selected for this analysis.
  • The introduction of the segmental heterogeneity index aims to better assess emphysema severity at a segmental level, and a trial (STEP-UP) is underway to enroll patients with upper lobe heterogeneous emphysema using these advanced techniques.
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Background: An innovative approach to lung volume reduction (LVR) for emphysema is introduced in the design of the Sequential Segmental Treatment of Emphysema with Upper Lobe Predominance (STEP-UP) trial where vapour ablation is administered bilaterally over the course of two sessions and is used to target only the most diseased upper lobe segments. By dividing the procedure into two sessions, there is potential to increase the total volume treated per patient but reduce volume treated and energy delivered per session. This is expected to correlate with improvements in vapour ablation's safety and efficacy profiles.

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