Chikungunya is a viral disease transmitted by Aedes mosquitoes, causing symptoms like high fever and joint pain, with potential severe complications including encephalitis and chronic arthritis.*
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An analysis of proteomics data from CHIKV-infected patients showed changes in critical processes, particularly involving proteins linked to cholesterol metabolism and mRNA splicing, as well as significant upregulation of actin cytoskeleton proteins associated with arthritis.*
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The study highlights the connection between actin cytoskeletal remodeling and alterations in purine metabolism, providing insights into the mechanisms underlying arthritis development during Chikungunya infection.*