Publications by authors named "Souradeep Biswas"
Article Synopsis
- Ribosomes are essential machines in cells that synthesize proteins, made up of rRNA and various proteins, through a controlled process called ribosome biogenesis.
- Impairments in ribosome biogenesis can lead to diseases, particularly cancer, as cancer cells often show changes in ribosomal proteins linked to this process.
- This article focuses on how ribosome biogenesis is affected in cancer stem cells, its relationship with conditions like hypoxia and drug resistance, and discusses potential anti-cancer drugs that target ribosome biogenesis.
Cellular starvation occurs when a cell is deprived of nutrition and oxygen availability. The genesis of this state of deprivation is exclusively contingent upon the inadequacy in the supply of essential components, namely amino acids, glucose, and oxygen. Consequently, the impact of this altered condition manifests in the regulation of cellular respiratory, metabolic, and stress responses.
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- * Doxorubicin (DOX), a commonly used chemotherapeutic for TNBC, can inadvertently induce epithelial to mesenchymal transition (EMT) in CSCs, leading to increased aggression and metastatic capabilities in cancer cells.
- * A new approach involving combining DOX with dietary compound indole 3,3'-diindolylmethane (DIM) is being explored, utilizing advanced drug delivery via exosomes and mesoporous silica nanoparticles to effectively target CSCs and potentially mitigate the adverse effects of DO
Targeting exhausted CD8+ T-cell (TEX)-induced aggravated cancer stem cells (CSC) holds immense therapeutic potential. In this regard, immunomodulation via Neem Leaf Glycoprotein (NLGP), a plant-derived glycoprotein immunomodulator is explored. Since former reports have proven immune dependent-tumor restriction of NLGP across multiple tumor models, we hypothesized that NLGP might reprogram and rectify TEX to target CSCs successfully.
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- * In experiments, PLL showed a strong ability to induce apoptosis in MCF-7 cancer cells, primarily through mitochondrial pathways and the activation of cleaved caspase-3.
- * The study found that PLL can bind to DNA, contributing to its apoptotic effects, and suggests that caution is needed when using PLL with other chemotherapy treatments due to its potency at various concentrations.
Article Synopsis
- * The presence of CSCs complicates cancer treatment because they can form aggressive tumors that are resistant to drugs and likely to spread (metastasize).
- * The review explores methods to target ACD in CSCs, discussing influences from various proteins, miRNAs, and lncRNAs, as well as existing and potential drugs aimed at this process.
Article Synopsis
- Advances in molecular cancer biology have led to new potential anti-cancer drugs through improved target detection, particularly focusing on the role of hypoxia-inducible factor-1α (HIF-1α).
- HIF-1α is crucial in tumor adaptation to low oxygen levels and influences processes like cell growth, survival, and cancer spread, making its overexpression linked to worse patient outcomes.
- The review highlights natural and synthetic HIF-1α inhibitors that could foster drug discovery efforts, explaining their mechanisms to aid in the development of effective cancer therapies.
Article Synopsis
- The COVID-19 pandemic, caused by the SARS-CoV-2 virus, began in Wuhan, China in December 2019 and has spread globally, affecting nearly 187 countries with no effective treatment or vaccine available yet.
- Repurposing existing drugs is a key strategy during this pandemic to avoid the lengthy process of developing new treatments.
- Orientin, a natural flavonoid with various health benefits, shows potential in interfering with the SARS-CoV-2 spike protein and its receptor, GRP78, suggesting it may serve as a promising precautionary or therapeutic option against COVID-19.