Transdermal Delivery of Gold Nanoparticles by a Soybean Oil-Based Oleogel under Iontophoresis.

Developing a facile mechanism for transporting nanoparticles across the whole skin by overcoming the stratum corneum is a challenging task. Herein, a stimuli-responsive and noninvasive transport of gold nanoparticles (AuNPs) has been reported through the fabrication of AuNP-incorporated soybean oil-based oleogels (AuG) using stearic acid as a gelator. A series of AuG was formulated by incorporating different proportions of AuNPs and a fixed amount of ciprofloxacin hydrochloride (drug) to establish that the composition with the highest concentration of AuNP (d-AuG4) was associated with the best iontophoretic response, validated via the corresponding in vitro drug release under AC field-induced iontophoresis.

Oleogel-mediated transdermal delivery of white emitting NaYF conjugated with Rose Bengal for the generation of reactive oxygen species through NIR-upconversion.

The transdermal route for the delivery of therapeutic agents to the inner skin tissues for non-invasive photodynamic therapy; though constitutes a desired modality for treating skin cancer, the success has been limited due to the insurmountable nature of the stratum corneum (SC). In this context, for the first time we report the localization of photosensitizer-conjugated upconversion (UC) particles to the deeper dermal region by overcoming SC through an oleogel-mediated transport mechanism for NIR-induced photodynamic production of reactive oxygen species (ROS). We developed soybean oil and stearic acid based oleogels by incorporating photoluminescent white light emitting NaYF (WEN) upconversion (UC) particles conjugated with Rose Bengal (RB), termed as WEN-RB-G.

Magnetic nanoparticle incorporated oleogel as iontophoretic drug delivery system.

In this article, we validated the use of electric current as an external stimulus to induce an enhancement of drug release from magnetic nanoparticle (MNP) incorporated organogels (magnetogel) under iontophoretic conditions. For this purpose, we adopted a simple, two-step synthesis route to incorporate magnetic (FeO) nanoparticles (MNP) and ciprofloxacin hydrochloride within the network of a soybean oil-based oleogel using stearic acid as gelator. We fabricated a series of MNP incorporated oleogels by varying the wt% of MNPs while keeping a constant weight ratio of soybean oil:stearic acid.