Publications by authors named "Soumita Paul"
Article Synopsis
- Mature small non-coding RNAs (sncRNAs) that are polyadenylated but not properly processed undergo active degradation by the Rrp6p and Rrp47p proteins, without needing the core exosome or TRAMP complexes.
- Rrp6p and Rrp47p form an exosome-independent complex that specifically targets these polyadenylated sncRNAs for degradation, and a truncated version of Rrp6p can still perform this function.
- Analysis shows that most polyadenylation sites are located near the mature ends of sncRNAs, with tails typically composed of 10-15 adenylate residues, and these polyadenylated snRNAs remain functional, contributing to spliceosome assembly in
Microbiol Res
October 2022
Article Synopsis
- Environmental sensing and adaptation are vital for organism survival, with metabolic enzymes playing key roles as nutrient sensors and transcriptional regulators.
- The yeast Candida albicans serves as a model for studying the N-acetylglucosamine (GlcNAc) signaling pathway, highlighting the multifunctional enzyme GlcNAc kinase (Hxk1) in regulating gene expression and cellular metabolism.
- Hxk1's dynamic functions and subcellular localization may provide insights into cell fate and metabolic specialization in eukaryotes, although its precise molecular mechanisms and signaling relationships are still being explored.
Mol Microbiol
February 2022
Article Synopsis
- - N-acetylglucosamine (GlcNAc) is a key sugar that activates various cellular processes in the fungal pathogen Candida albicans, with its transportation being orchestrated by the GlcNAc transporter Ngt1, which plays a crucial role in GlcNAc signaling.
- - Ngt1’s expression is highly responsive to low concentrations of GlcNAc, leading to phosphorylation and ubiquitylation that mediate its internalization, involving proteins like Snf1, Rod1, and Rsp5; Rsp5 enhances Ngt1's trafficking while Snf1 inhibits it.
- - This study provides new insights into the endosomal trafficking mechanisms of Ngt1 in C. albicans,
J Fungi (Basel)
January 2021
Article Synopsis
- N-acetylglucosamine (GlcNAc) is a significant signaling molecule in pathogenic yeast, influencing various cellular processes such as virulence, morphogenesis, and cell death.
- GlcNAc signaling primarily works by activating a sensor called Ngs1, which regulates gene expression through mechanisms like promoter acetylation.
- Understanding GlcNAc signaling can provide insights for therapeutic strategies against fungal infections like candidiasis.
