Implementation of an ultra-sensitive microwell-based electrochemical sensor for the detection of Alzheimer's disease.

Alzheimer's Disease (AD) is one of the most common neurodegenerative disorders in elderly people. It is diagnosed by detecting amyloid beta (Aβ) protein in cerebrospinal fluid (CSF) obtained by lumbar puncture or through expensive positron emission tomography (PET) imaging. Although blood-based diagnosis of AD offers a less invasive and cost-effective alternative, the quantification of Aβ is technically challenging due to its low abundance in peripheral blood.

Electronic effect of substituents on the charge-transfer dynamics at the CsPbBr perovskite-small molecule interface.

To push the boundary of the efficiency of perovskite nanocrystal-based photovoltaics, understanding the charge transfer at the interface of these nanocrystals is necessary. In an effort to understand the electronic effects of the substituents in the charge acceptor moiety, three electronically different small molecules (namely, chloranilic acid (CA), -benzoquinone (BQ), and duroquinone (DQ)) were chosen and their detailed charge transfer dynamics were studied at the CsPbBr perovskite nanocrystal-small organic molecule interface using steady state and time-resolved spectroscopic methods. The steady-state absorption and time-resolved emission studies reveal that all three molecules interact with the NCs in the excited state.

Indian spice curcumin may be an effective strategy to combat the genotoxicity of arsenic in Swiss albino mice.

Inorganic arsenic (As) is considered as a human carcinogen because it is associated with cancers of skin, lung, liver and bladder in exposed population. Consumption of As contaminated ground water for long term causes oxidative stress. Generation of reactive oxygen species (ROS), beyond the body's endogenous antioxidant balance results severe imbalance of the cellular antioxidant defense mechanism.

Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal.

Groundwater arsenic contamination has been a health hazard for West Bengal, India. Oxidative stress to DNA is recognized as an underlying mechanism of arsenic carcinogenicity. A phytochemical, curcumin, from turmeric appears to be potent antioxidant and antimutagenic agent.