Publications by authors named "Soujanya Rao"
Background: VCF formatted files are the lingua franca of next-generation sequencing, whereas HL7 FHIR is emerging as a standard language for electronic health record interoperability. A growing number of FHIR-based clinical genomics applications are emerging. Here, we describe an open source utility for converting variants from VCF format into HL7 FHIR format.
View Article and Find Full Text PDFTime course of neuroanatomical and functional recovery after bilateral pudendal nerve injury in female rats.
Am J Physiol Renal Physiol
November 2007
Article Synopsis
- The pudendal nerve, which controls the external urethral sphincter, can sustain injuries during childbirth, potentially causing stress urinary incontinence (SUI).
- Measurements showed significant drops in urethral leak-point pressure (LPP) immediately after nerve injuries, but functionality began to normalize by 2 to 6 weeks, indicating some recovery.
- Analysis revealed early signs of nerve regeneration and recovery of the external urethral sphincter, but anatomical recovery was still incomplete after 6 weeks, suggesting that 2 weeks post-injury is a crucial timeframe for initial healing processes.
Short-term functional and neuroregenerative response of the urethra to ovariectomy and vaginal distension in female rats.
Int Urogynecol J Pelvic Floor Dysfunct
August 2005
The objective of this study was to investigate the effects of ovariectomy (OVX) and vaginal distension (VD) on leak point pressure (LPP) and pudendal nerve regenerative response in the female rat. Twenty rats underwent OVX 3 days prior to either VD or sham distension. Seventeen rats did not receive OVX but underwent either VD or sham distension.
View Article and Find Full Text PDFAims: Mathematical models are useful for developing predictive parameters for characterizing the biomechanics of voiding dysfunction. The goal of this project was to test a one-dimensional steady flow model used to predict the minimum cross-sectional urethral area from urodynamic data.
Methods: Nine adult female subjects underwent video-urodynamic testing.