Publications by authors named "Souhila Abdelfettah"
Article Synopsis
- The tumor suppressor gene located at 17p13.3 is often deleted or silenced in human tumors and plays a role in DNA damage response and regulation alongside P53 and SIRT1.
- Research indicates that this gene is primarily expressed in the stroma of both normal and tumor prostate tissues, while showing low expression in various prostate epithelial cell types.
- The depletion of this gene in myofibroblasts reduces specific protein expression and contractility, suggesting its crucial role in the tumor-promoting activity of the tumor microenvironment and linking its loss to prostate tumors through aging-related promoter hypermethylation.
Polycomb repressive complex 2 (PRC2) allows the deposition of H3K27me3. PRC2 facultative subunits modulate its activity and recruitment such as hPCL3/PHF19, a human ortholog of Drosophila Polycomb-like protein (PCL). These proteins contain a TUDOR domain binding H3K36me3, two PHD domains and a "Winged-helix" domain involved in GC-rich DNA binding.
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