New anticancer Pd and Pt complexes of tertamyl dithiocarbamate and DACH ligands against HT29 and Panc1 cell lines.

To investigate the reduction of side effects of commercial antitumor drugs such as cisplatin, two new platinum and palladium complexes with a formula of [M(DACH)(tertamyl.dtc)]NO were synthesized (DACH is 1, 2Rdiaminocyclohexane, tertamyl-dtc is tertpentyl dithiocarbamate, and M is palladium or platin ionic metals) and characterized by spectroscopic methods. The cytotoxicity of these compounds against HT29 and Panc1 cell lines showed that the IC values against Panc1 cell line of [Pt(DACH)(tertamyl.

Some new anticancer platinum complexes of dithiocarbamate derivatives against human colorectal and pancreatic cell lines.

Cisplatin, carboplatin and oxaliplatin and their analogs are effective anticancer agents, but their clinical using is limited by some serious side effects. S,S donor ligands such as dithiocarbamates can be used to reduce some side effects. In this study, some novel water soluble complexes with formula of [Pt(bpy)(R.