Publications by authors named "Sou Nakatani"
The differences in genetic susceptibility to lung adenocarcinoma and squamous cell carcinoma remain unclear. We developed a customized, targeted gene sequencing panel for efficient and sensitive identification of germline variants, including whole-gene deletion types for cancer-related drug-metabolizing enzyme genes in lung adenocarcinoma and squamous cell carcinoma. The minor allele frequencies of the variants, confirmed as clinically significant in the Japanese population, did not differ significantly from those of normal participants listed in the public database.
View Article and Find Full Text PDFNext-generation sequencing (NGS) is an integral part of precision medicine, and its power for detecting comprehensive genetic alterations may contribute to treatment decisions for patients with advanced, recurrent, or metastatic cancer. An NGS oncology panel developed in the U.S.
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- Despite the presence of KRAS mutations in colorectal cancer (CRC) patients, no effective treatments specifically targeting these mutations have been developed yet.
- The study analyzed gene expression differences between CRC patients with wild-type KRAS and those with mutations in codon 12, identifying at least 11 candidate molecules with significant expression changes.
- Three particular genes (BMP4, PHLDA1, and GJB5) showed increased expression in cell lines with KRAS G12 mutations, suggesting potential pathways for developing new treatments for KRAS-driven CRC.