Flutrimazole 1% dermal cream in the treatment of dermatomycoses: a randomized, multicentre, double-blind, comparative clinical trial with 1% clotrimazole cream. Flutrimazole Study Group.

In a multicentre, double-blind, randomized, parallel group clinical trial, the efficacy and tolerability of flutrimazole 1% dermal cream were compared with those of a reference compound, clotrimazole 1% dermal cream, applied topically twice daily for 4 weeks in patients with clinically and mycologically diagnosed fungal infection of the skin. A total of 484 patients were included in the study (244 patients received flutrimazole cream and 240 clotrimazole cream). According to an intention to treat analysis of the data, there was no difference between the treatments in terms of the rate of mycological cure after 4 weeks: 79% of patients in the clotrimazole group and 80% of patients in the flutrimazole group were mycologically cured (P = 0.

Keratoderma palmoplantaris striata.

A patient with keratoderma palmoplantaris striata is presented. In the family tree there are 36 relatives affected to a varying degree. The familial incidence is the largest reported in the literature reviewed.

[Familial acanthosis nigricans].

After a brief introduction about the classification and clinicopathological findings of acanthosis nigricans, we present a clinical case of the familial type of acanthosis nigricans in a woman with lesions beginning in childhood and with three family members affected. We comment the characteristics that permit us to individualize this condition from the other forms of benign acanthosis nigricans.

[Progressive symmetric erythrokeratodermia. Report of a case with delayed onset treated by etretinate].

A case of delayed onset (17 years) progressive symmetric erythrokeratodermia is presented. The treatment with etretinate initially improved the clinical picture, but it had to be discontinued because of personality changes, particularly depressive crisis. In addition, clinical manifestations, histology, kinetics and ultrastructural changes in this condition are also commented on.