Publications by authors named "Sota Uno"
Synthesis and Aldose Reductase Inhibitory Activity of Botryllazine A Derivatives.
Chem Pharm Bull (Tokyo)
June 2019
Article Synopsis
- Aldose reductase (AR) is linked to diabetic complications, prompting the study of Botryllazine A and its analogues for AR inhibition.
- Analogues with aromatic bicyclic structures at the C5 position of the pyrazine ring showed better AR inhibitory effects than the original Botryllazine A.
- Having benzoyl groups at C2 and C3 of the pyrazine ring wasn't necessary for high inhibitory activity, but phenolic hydroxyl groups at these positions were crucial for achieving effectiveness similar to the powerful AR inhibitor sorbinil.