Effects of Volatile Anesthetics on Oral Tissue Blood Flow in Rabbits: A Comparison Among Isoflurane, Sevoflurane, and Desflurane.

Purpose: The aim of this study was to compare the concentration-dependent effects of isoflurane, sevoflurane, and desflurane on oral tissue blood flow.

Materials And Methods: Thirty male Japan White rabbits were randomized to receive 1 of 3 volatile anesthetics: isoflurane (group Iso), sevoflurane (group Sevo), or desflurane (group Des). The end-tidal concentration of each volatile anesthetic was regulated to 0.

Concomitant administration of nitrous oxide and remifentanil reduces oral tissue blood flow without decreasing blood pressure during sevoflurane anesthesia in rabbits.

Purpose: To determine whether continuous administration of nitrous oxide and remifentanil—either alone or together—alters blood flow in oral tissues during sevoflurane anesthesia.

Methods: Eight male tracheotomized Japanese white rabbits were anesthetized with sevoflurane under mechanical ventilation. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), common carotid arterial blood flow (CCBF), tongue mucosal blood flow (TMBF), mandibular bone marrow blood flow (BBF), masseter muscle blood flow (MBF), upper alveolar tissue blood flow (UBF), and lower alveolar tissue blood flow (LBF) were recorded in the absence of all test agents and after administration of the test agents (50 % nitrous oxide, 0.

Bioconversion by functional P450 1A9 and P450 1C1 of Anguilla japonica.

We indicated that two P450s (1A9 and 1C1) from Japanese eel (Anguilla japonica) metabolized 7-ethoxycoumarin, 7-ethoxyresorufin, and flavanone. At first, we constructed expression vectors for two types of P450 (1A9 and 1C1). The reduced CO-difference spectra of Escherichia coli cells transformed with these plasmids showed Soret peaks (450 nm) that were typical of P450s.

Bioconversion of small molecules by cytochrome P450 species expressed in Escherichia coli.

P450 (cytochrome P450) enzymes catalyse the mono-oxygenation of a wide range of compounds such as steroids, fatty acids, vitamins and drugs. In the present paper we demonstrate a system for bioconverting diverse compounds [flavanone, DHEA (dehydroepiandrosterone) and 7-ethoxycoumarin] using P450 species expressed in Escherichia coli. First, we expressed four P450 species: rabbit CYP2B (P450 family 2, subfamily B), fruitfly (Drosophila) CYP317A, rat CYP3A23 and mouse CYP2J5.

Design, fabrication, and evaluation of crystal-cored fibers for efficient second-harmonic generation based on Cerenkov-radiation-type phase matching.

A formulation for calculating the optical second-harmonic power based on the Cerenkov-radiation-type phase matching is derived for a crystal-cored fiber. The prerequisite condition for high efficiency is expressed by a simple relation by use of the refractive indices of a core crystal, a core radius, and a fundamental wavelength. An organic crystal-cored fiber is designed and practically fabricated by the guiding principle derived here.