Publications by authors named "Sota Ikawa"
Article Synopsis
- A new and simple method has been developed for making Ngai trifluoromethoxy and longer carbon chain variants, increasing options for perfluoroalkoxylation reactions.
- The process uses inexpensive sodium perfluoroalkane sulfinates and hydroxylamines to enable efficient cross-coupling reactions with cerium(IV) ammonium nitrate (CAN), eliminating the need for expensive transition-metal catalysts.
- This methodology works well for creating both Ngai-type radical and Qing-type nucleophilic perfluoroalkoxylation reagents.
Alkali metal alkoxides play a pivotal role in nucleophilic alkoxylation reactions, offering pathways for the synthesis of ethers, including the increasingly sought-after trifluoromethyl ethers. However, the synthesis of long-chain perfluoroalkyl ethers remains a substantial challenge in this field. Through the innovative use of triglyme to encapsulate potassium ions, we enhanced the stability of short-lived, longer-chain perfluoroalkoxy anions, thereby facilitating efficient nucleophilic perfluoroalkoxylation reactions.
View Article and Find Full Text PDFFatty acids salts exert bactericidal and bacteriostatic effects that inhibit bacterial growth and survival. However, bacteria can overcome these effects and adapt to their environment. Bacterial efflux systems are associated with resistance to different toxic compounds.
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