Incident Gallstones During Somatostatin Analog Treatment are Associated with Acute Biliary Complications Especially After Discontinuation.

Introduction: Gallstones are a known adverse effect of somatostatin analogs, but the exact incidence and clinical implications are unknown.

Objectives: The aim of this study was to investigate the incidence of gallstones on imaging and related complications in unbiased trial data.

Methods: Data from the DIPAK 1 trial, in which 305 polycystic kidney disease patients were randomized to standard of care (SoC) or lanreotide for 120 weeks, were used.