Publications by authors named "Soroush Besharat"
Article Synopsis
- * Using data from a trial involving 142 participants with chemotherapy-induced peripheral neuropathy, researchers measured pain qualities daily for a week and compared these results to weekly assessments to evaluate treatment effects.
- * The findings indicate that using daily mean assessments can significantly reduce the number of participants needed to detect treatment effects, suggesting improved sensitivity in measuring pain outcomes for future trials.
Objective: Clinical trials of cannabinoids for chronic pain have mixed and often inconclusive results. In contrast, many prospective observational studies show the analgesic effects of cannabinoids. This survey study aimed to examine the experiences/attitudes of individuals with chronic pain who are currently taking, have previously taken, or never taken cannabinoids for chronic pain to inform future research.
View Article and Find Full Text PDFPeripheral edema (i.e., lower limb swelling) can cause pain, weakness, and limited range of motion.
View Article and Find Full Text PDFIn the setting of radiation-induced trauma, exposure to high levels of radiation can cause an acute radiation syndrome (ARS) causing bone marrow (BM) failure, leading to life-threatening infections, anemia, and thrombocytopenia. We have previously shown that human macrophages educated with human mesenchymal stem cells (MSCs) by coculture can significantly enhance survival of mice exposed to lethal irradiation. In this study, we investigated whether exosomes isolated from MSCs could replace direct coculture with MSCs to generate exosome educated macrophages (EEMs).
View Article and Find Full Text PDFCorneal Mesenchymal Stromal Cells Are Directly Antiangiogenic via PEDF and sFLT-1.
Invest Ophthalmol Vis Sci
October 2017
Purpose: To evaluate the angiogenic properties of corneal derived mesenchymal stromal cells (Co-MSC).
Methods: Co-MSCs were extracted from human cadaver, and wild-type (C57BL/6J) and SERPINF1-/- mice corneas. The MSC secretome was collected in a serum-free medium.