Prospective Genetic Screening in Multiple Endocrine Neoplasia Syndromes.

Multiple endocrine neoplasia syndromes are a rare but potentially fatal pathology due to the lack of early diagnosis. We have performed a narrative review of the medical literature, summarizing the main clinical concepts useful in current clinical practice, showing the importance of screening and early diagnosis during childhood.

Quality of Life in Cancer Patients: The Modern Psycho-Oncologic Approach for Romania-A Review.

Quality of life (QOL) is an important indicator of human satisfaction and well-being. QOL is significantly and persistently affected for patients after a cancer diagnosis. Despite some evidence suggesting that psycho-oncologic interventions can provide lasting benefits, the inclusion of such interventions in cancer therapy is not universal.

Retroperitoneal Haematoma - Still a Medical Challenge for Abdominal Trauma.

The study is presenting a personal experience of a Trauma Centre Level I and is try to conclude on optimal medical attitude for patients with retroperitoneal hematoma, still a controversial topic for traumatologists. Material and Method: A retrospective analysis of 22 cases of post-traumatic retroperitoneal hematoma admitted on Bucharest Emergency Hospital between September 2018 August 2021 (including time of Covid-19 pandemic), is presented The patients (males predominance, mean age 43, mean ISS of 23), benefited of nonoperative management on admission for 10 cases (45%) with a failure rate of 4/10 due to recurrent bleeding from spleen injuries and continuous bleeding from mesenteric vessels lesions. CT scan (73% - 16 cases) within 1 hour from the admission and emergency surgery were necessary for 12 cases (55%).

Right Hemihepatectomy for Colon Cancer Metachronous Liver Metastasis in a Patient with Crohn\'s Disease: Case Report and Review of the Literature.

Unlabelled: Twenty percent of patients with colorectal cancer present stage IV disease at the time of diagnosis. The Crohn's disease increases 20 times the risk of colorectal cancer and worsens the patients' prognosis. The objective of this case report is to illustrate the surgical resection of a liver metachronous metastasis of colon cancer origin in a patient with Crohn's disease.

Complex Perineal Trauma with Anorectal Avulsion.

. The objective of this case report is to illustrate a severe perineal impalement injury, associated with anorectal avulsion and hemorrhagic shock. .

Resection of Large Metachronous Liver Metastasis with Gastric Origin: Case Report and Review of the Literature.

Introduction: Increasing evidence suggests that surgical resection may be offered to a subgroup of patients with liver metastasis of gastric adenocarcinoma. The aim of this case report is to illustrate the surgical resection of a single liver metachronous recurrence twelve months after a radical total gastrectomy for cancer.

Case Report: A 63-year-old male patient with an Eastern Cooperative Oncology Group performance status of 1 was referred to our hospital for a single, large liver metastasis, twelve months after a radical total gastrectomy and DII lymphadenectomy for upper third gastric adenocarcinoma.

Primary Aortoduodenal Fistula: First you Should Suspect it.

A 59 year-old patient was admitted with upper gastrointestinal bleeding. The clinical exam showed mild hypotension and blood samples revealed acute anemia (hemoglobin = 7.5 g/dl).

Extralevator vs conventional abdominoperineal resection for rectal cancer-A systematic review and meta-analysis.

Background: The aim of this study was to compare the short-term morbidity and long-term oncologic benefits of extralevator abdominoperineal excision (ELAPE) with conventional abdominoperineal resection (CAPR) for patients with rectal cancer.

Methods: Electronic search of the Cochrane Library, MEDLINE, EMBASE, Korean Journal, and J-EAST database from 2007 until August 2015 was carried out. We considered randomized controlled trials and nonrandomized comparative studies comparing ELAPE with CAPR to be eligible, if they included patients with rectal cancers.

Laparoscopic Transgastric versus Endoscopic Drainage of a Large Pancreatic Pseudocyst. A Case Report.

Background: Pancreatic pseudocysts are the most common complication of acute and chronic pancreatitis. They account for 75% of the cystic lesions of the pancreas.

Case Report: A 37 year-old woman was admitted three months after an episode of severe acute pancreatitis with a large tumor mass located in her left abdomen, abdominal tenderness and asthenia.

Probability of Survival Scores in Different Trauma Registries: A Systematic Review.

Introduction: A mixed score to predict the probability of survival has a key role in the modern trauma systems. The aim of the current studies is to summarize the current knowledge about estimation of survival in major trauma patients, in different trauma registries.

Method: Systematic review of the literature using electronic search in the PubMed/Medline, Web of Science Core Collection and EBSCO databases.

Laparoscopic Approach has Benefits in Gynecological Emergencies - Even for Massive Hemoperitoneum.

Objective: The purpose of this study is to compare the laparoscopic with the open approach in hemoperitoneum of gynecological origin.

Materials And Methods: Retrospective study of patients admitted to a tertiary emergency hospital between January 2013 - January 2015.

Results: There were 56 patients, 27 in the laparoscopic group (LG) and 28 in the open group (OG).

Most small bowel cancers are revealed by a complication.

Objective: To characterize the pattern of primary small bowel cancers in a tertiary East-European hospital.

Methods: A retrospective study of patients with small bowel cancers admitted to a tertiary emergency center, over the past 15 years.

Results: There were 57 patients with small bowel cancer, representing 0.

Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion from a Meckel diverticulum neuroendocrine tumor: case report.

Background: Ectopic production of adrenocorticotropic hormone (ACTH) by neuroendocrine tumours (NET) is a rare condition, occult presentations often hampering the diagnosis. Although NET are relatively frequent in the ileon and Meckel diverticulum, we describe the first Cushing's syndrome due to ectopic adrenocorticotropic syndrome (CS-EAS) arising from a Meckel diverticulum.

Case Presentation: A 44-year-old man was admitted with recent onset of diabetes, myopathy, edema and hypokalemic metabolic alkalosis consistent with Cushing's syndrome.

Outcome of Laparoscopic Adrenalectomy in Obese Patients.

Objectives: To compare early morbidity of obese and nonobese patients with minimally invasive adrenalectomies.

Method: Retrospective study of a prospectively maintained database, between June 2003 - December 2012, in a universitary affiliated tertiary hospital. Selection criteria: Minimally invasive adrenalectomy.

The epithelial to mesenchymal transition in pancreatic cancer: A systematic review.

Background/objectives: The present article summarizes and analyzes the current knowledge about the role of the epithelial to mesenchymal transition (EMT) in the systemic invasiveness of pancreatic cancer.

Method: An electronic search of PubMed/MEDLINE, EMBASE, and the Web of Science was used to identify relevant original articles and reviews.

Results: The EMT represents a key step during normal embryogenesis.

Selective Nonoperative Management of Abdominal Injuries in Polytrauma Patients: a Protocol only for Experienced Trauma Centers.

Introduction: Nowadays we are facing a steep increase in non-operative management throughout the injured body areas, with a continuous increase in the injuries' grade.

Objective: To evaluate the safety and applicability of non-operative management in major trauma patients.

Methods: Prospective observational study, in a level I trauma center, during 30 months.

Inhibin alpha-subunit, Melan A and MNF116 in pheochromocytomas.

Aim: The aim of this study was to make immunohistochemical analyses with Inhibin alpha-subunit, Melan A and MNF116 (pan-Cytokeratin antibody) in pheochromocytomas, because immunohistochemistry is useful for the distinction between adrenal tumors.

Patients And Methods: We used 20 patients with pheochromocytomas submitted to laparoscopic (n=19) or classical (n=1) surgery and we have explored immuno-staining with Inhibin alpha-subunit, Melan A and MNF116 in these tumors. This can be helpful when we cannot make the distinction between adrenal tumors.

Natural orifice translumenal endoscopic surgery (NOTES) second-look peritoneoscopy for staging of limited peritoneal carcinomatosis.

Background: Over the past decades, staging laparoscopy evolved as a useful tool in multimodality treatment of patients with abdominal malignancies, especially for detection of incurable peritoneal and liver metastasis. Natural orifice translumenal endoscopic surgery (NOTES) is a new, evolving technique which represents the next logical progression in minimally invasive surgery and has theoretical advantages in comparison with standard laparoscopic surgery. A review of the current literature revealed a continuous increasing number of fundamental and clinical studies addressing NOTES approach in multimodal management of oncologic patients.

Multimodal management of upper gastrointestinal bleeding caused by stress gastropathy.

Background: The 1999 ASHP (American Society of Health-System Pharmacists) recommendation regarding the prevention of stress-related mucosal disease and bleeding in critical care patients by using PPI and H2RA still holds. We tried to compare the results obtained by our group with the international data available and determine the benefits of this prophylactic therapy.

Methods: The present paper presents a retrospective single center report of 36 patients with upper gastrointestinal (GI) bleeding caused by stress gastritis.

Comparison of quality control for trauma management between Western and Eastern European trauma center.

Background: Quality control of trauma care is essential to define the effectiveness of trauma center and trauma system. To identify the troublesome issues of the system is the first step for validation of the focused customized solutions. This is a comparative study of two level I trauma centers in Italy and Romania and it has been designed to give an overview of the entire trauma care program adopted in these two countries.