Topical aminolaevulinic acid-photodynamic therapy produces an inflammatory infiltrate but reduces Langerhans cells in healthy human skin in vivo.

Background: Topical photodynamic therapy (PDT) elicits a therapeutic response in both skin cancer and immune-mediated skin disorders. While PDT induces direct cell death, host inflammatory and immune responses to PDT may contribute to the therapeutic effects.

Objectives: To examine the impact of topical PDT on leucocyte trafficking and mediators of chemotaxis in healthy human skin.

Laparoscopic exclusion gastroenterostomy for palliation of gastric outlet obstruction secondary to recurrent cholangiocarcinoma.

The Devine exclusion gastroenterostomy is recommended as a palliative procedure for unresectable gastric carcinoma, and avoids the problem of delayed gastric emptying. It is conventionally performed by a laparotomy. We report the successful laparoscopic application of this technique in a patient with gastric outlet obstruction secondary to recurrence of a previously resected hilar cholangiocarcinoma.