Serologic Profile of Donors In Argentina.

Background: Constructing serologic profiles of donors is the first step in establishing traceability in the donation and transplant process. These data allow us to implement various strategies to enhance the recipients' quality of care. We present the serologic profiles of donors in Argentina between 2017 and 2021.

COVID-19 pandemic and worldwide organ transplantation: a population-based study.

Background: Preliminary data suggest that COVID-19 has reduced access to solid organ transplantation. However, the global consequences of the COVID-19 pandemic on transplantation rates and the effect on waitlisted patients have not been reported. We aimed to assess the effect of the COVID-19 pandemic on transplantation and investigate if the pandemic was associated with heterogeneous adaptation in terms of organ transplantation, with ensuing consequences for waitlisted patients.

HLA antigenic and haplotype frequencies estimated in hematopoietic progenitor cell donors from Argentina.

Background: Hematopoietic progenitor cell transplantation is considered a standard-of-care treatment for defined hematological and non-hematological conditions affecting bone marrow-derived cells.

Methods: Patients and potential donors are HLA typed for their HLA-A, -B, -C, -DRB1, and -DQB1 alleles. The best allogeneic donor is one for which each allele matches the patient at HLA-A, -B, -C, and -DRB1 (8/8).

Results after the adoption of a MELD/PELD-based liver allocation policy in Argentina.

In July 2005, Argentina switched from a categorical liver allocation system to a MELD/PELD-based policy for patients with CLD. To analyze WL outcomes and survival after LT in children. From January 2000 to December 2010, 923 children were registered.

Improved waiting-list outcomes in Argentina after the adoption of a model for end-stage liver disease-based liver allocation policy.

In July 2005, Argentina became the first country after the United States to introduce the Model for End-Stage Liver Disease (MELD) for organ allocation. In this study, we investigated waiting-list (WL) outcomes (n = 3272) and post-liver transplantation (LT) survival in 2 consecutive periods of 5 years before and after the implementation of a MELD-based allocation policy. Data were obtained from the database of the national institute for organ allocation in Argentina.

Factors associated with patient and graft survival using kidneys from cadaveric donors in transplanted patients over 18 years of age in Argentina.

Background: With improvements in short-term kidney graft and patient survival, focus has shifted to understand patient and graft features that affect long-term survival.

Materials And Methods: This retrospective analysis from January 1998 to December 2009 employed Kaplan-Meier analysis to evaluate survival ratios at 30 days as well as 1, 5, and 10 years. A multivariable Cox regression model considered variables of donor and recipient, gender and age, cold ischemia time (CIT), chronic renal failure etiology, time on dialysis (TD) and cause of donor death.

Analysis of mortality while on waiting list for kidney transplant in adults in Argentina 2005-2009.

Introduction: Comparison of survival after renal transplant patients on the waiting list is an important factor to evaluate this therapy.

Objective: To measure the magnitude of deceased donor kidney transplant on patient survival compared to patients on dialysis and on waiting lists in over 18 years in Argentina.

Material And Methods: The information was obtained from SINTRA for the period January 2003 to December 2009.

Factors associated with patient and graft survival using kidneys from cadaveric donors in transplant patients under 18 years of age in Argentina.

Background: Thanks to advances in surgical techniques and immune system suppression, the mortality rate in children with end-stage renal disease (ESRD) has dramatically declined. Kidney transplantation has become the primary method to treat ESRD in the pediatric population.

Materials And Methods: Information was obtained from SINTRA (National Information System of Orrgan Procurement and transplantation in Argentina) for the period 1998-2009.

Could metabolic syndrome, lipodystrophy, and aging be mesenchymal stem cell exhaustion syndromes?

One of the most important and complex diseases of modern society is metabolic syndrome. This syndrome has not been completely understood, and therefore an effective treatment is not available yet. We propose a possible stem cell mechanism involved in the development of metabolic syndrome.

[General considerations on brain death and recommendations on the clinical decisions after its diagnosis. Red/Consejo Iberoamericano de Donación y Trasplante].

The objective of the Latin American Network/Council of Donation and Transplant is to develop cooperation among its member states in all aspects related to donation and transplant of organs, tissue and cells. Given that diagnosing brain death (BD) is one of the key issues for the procurement of organs for transplant, the Network/Council seeks to contribute to defining the accepted concept of BD and its diagnosis and to disseminate this information among healthcare workers. In this report, we present the general guidelines on brain death and recommendations for clinical decisions after its diagnosis established and approved by the Latin American Network/Council of Donation and Transplant at its sixth meeting held in La Havana, Cuba, in May 2008.

[Brain death in Ibero-America].

Objective: To examine the diagnosis of brain death (BD) in Latin America.

Background: The term BD has long been used to define the death of an individual despite legal differences and variations in the diagnostic criteria applied in each country.

Method: A survey was conducted to gain information on the medical and legal diagnosis of BD in the 21 countries that make up the Latin American Network/Council of Donation and Transplant.

Matrix superhighways configurations: new concepts for complex organ regeneration.

New ideas and experimental models for tissue and organ regeneration are urgently needed. There are several exciting challenges in the field of organogenesis that need to be defined. The integrated signals and molecular repertoires that shape the particular architecture of specific organs like the kidney or the liver are not completely understood yet.

Organ donation in Latin America.

Recently in Latin America, there has been a strong influence of the "Spanish model" of organ procurement. In 2001, The "Punta Cana Group" was created by Latin American transplantation coordinators with the objective of registering and improving the system of donation and procurement. In many countries there is no universal financial support from the government for medical treatment, including dialysis and transplantation.

Glasgow coma scale 7 or less surveillance program for brain death identification in Argentina: Epidemiology and outcome.

Background: In Argentina, the rate of cadaveric organ donation per million inhabitants has recently increased to 10.5 (it was previously <7).

Purpose: To overcome this challenge, the National Institute for Organ Donation and Transplantation (INCUCAI) created a proactive donor detection plan performed by intensive care unit (ICU) physicians (hospital transplantation coordinators) from 90 selected hospitals across the country.

Bloodstream cells phenotypically identical to human mesenchymal bone marrow stem cells circulate in large amounts under the influence of acute large skin damage: new evidence for their use in regenerative medicine.

Objectives: Recent work has shown that human bone marrow contains mesenchymal stem cells (MSCs). However, little is known about their presence in peripheral blood. Since these cells are potentially responsible for tissue repair after injury, their number should be increased during these situations.

Human mesenchymal stem cells are tolerized by mice and improve skin and spinal cord injuries.

Introduction: We sought to use human mesenchymal stem cells (HMSC) for skin and spinal cord repair in mice.

Materials And Methods: Human bone marrow obtained from a young healthy donor was used to separate and culture human mesenchymal stem cells (HMSC). Ten mice were included in each of four groups.

Impact of regulations on tissue donation: mandatory referral of hospital deaths.

In Buenos Aires province, there has been surprisingly less tissue procurement activity following cardiac arrest than after brain-death cases. The purpose of this study was to analyse the impact of a regulation that made referral of all irreversible cardiac arrests mandatory to our organ procurement organisation. Data were collected from 7 hospitals in La Plata city during 7 months (from June 2000 to December 2000).