Publications by authors named "Sora Lecocq"
Article Synopsis
- Plasma HDL-C levels are generally linked to lower risk of coronary artery disease (CAD), but the specific relationship and biological reasons are not well understood, especially for individuals with extremely high HDL-C levels.
- The study analyzed HDL lipid composition in subjects with early-onset CAD and high HDL-C compared to healthy individuals with similar HDL-C levels, identifying key differences in lipid profiles.
- Findings revealed lower levels of certain HDL lipids (phosphatidylcholine and phosphatidylinositol) and higher levels of sphingomyelin in CAD patients, suggesting potential new biomarkers for CAD and insights into HDL function.
To evaluate functional and compositional properties of HDL in subjects from a kindred of genetic apoA-I deficiency, two homozygotes and six heterozygotes, with a nonsense mutation at APOA1 codon -2, Q[-2]X, were recruited together with age- and sex-matched healthy controls (n = 11). Homozygotes displayed undetectable plasma levels of apoA-I and reduced levels of HDL-cholesterol (HDL-C) and apoC-III (5.4% and 42.
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