Frailty in HIV infected people: a new risk factor for bone mineral density loss.

Objective: The study aims to assess the association between bone mineral density (BMD) and frailty in a cohort of HIV-infected patients.

Design: A cross-sectional study in an HIV outpatient unit where nearly 1000 patients are monitored.

Methods: Study participants undergoing bone densitometry were proposed an evaluation of frailty using criteria of the Cardiovascular Health Study (CHS) and the Study of Osteoporotic Fractures (SOF).

Osteoporosis prevention among chronic glucocorticoid users: results from a public health insurance database.

Introduction: Long-term glucocorticoid therapy is the leading cause of secondary osteoporosis. The management of glucocorticoid-induced osteoporosis (GIOP) seems to be inadequate in many European countries.

Objective: To evaluate the rate of screening and treatment of GIOP.

Bone infarcts: Unsuspected gray areas?

There is agreement to label as bone infarcts avascular necrosis (AVN) occurring in the metaphyses or diaphyses of long bones, the terms AVN or osteonecrosis being used at the epiphyses. One might expect bone infarction to hold no mysteries. Oddly enough, however, scientific evidence about bone infarcts is extraordinarily scant.

Evaluation of the treatment effect of NSAIDs/TNF blockers according to different domains in ankylosing spondylitis: results of a meta-analysis.

Objectives: To assess the treatment effect of NSAIDs and TNF blockers in AS according to different domains of interest.

Methods: A systematic literature research was performed in electronic databases up to October 2009. All randomized controlled trials (RCTs) reporting the efficacy (on pain and/or physical function and/or acute-phase reactants) of NSAIDs/anti-TNF vs placebo in AS were selected.