Stepping into day treatment approach versus inpatient treatment for adults with anorexia nervosa: the DAISIES RCT.

Background: A substantial proportion of anorexia nervosa patients require intensive treatments, commonly inpatient or day-patient treatment. The relative merits of these treatments for adults with anorexia nervosa are unknown. Therefore, a trial investigating the clinical effectiveness and cost-effectiveness of inpatient treatment-as-usual versus a stepped-care day-patient approach in adults with anorexia nervosa (DAISIES) was commissioned.

Neuroleptic malignant syndrome following catatonia: Vigilance is the price of antipsychotic prescription.

Objectives: To describe a case of neuroleptic malignant syndrome following antipsychotic treatment of catatonia, highlighting the potentially serious complications of this rare adverse drug reaction.

Methods: We present a case report of a patient who developed this syndrome with various sequelae.

Results: The patient developed neuroleptic after being treated with lorazepam and olanzapine for catatonia.

Preventing overcorrection of hyponatraemia with desmopressin.

A 61-year-old woman was admitted with history of vomiting, diarrhoea and severe hyponatraemia (Na(+) 109). The cause of the hyponatraemia was due to intravascular volume depletion resulting in a non-osmotic release of antidiuretic hormone (ADH) with the added effects of a thiazide diuretic. She was also on fluoxetine which may induce inappropriate secretion of ADH.