Publications by authors named "Sophie S Bozorgi"
Objectives: Longitudinal assessment of the role of specific proteins on radiotherapy caries (RC) onset in head and neck cancer patients(HNC) up to one-year post-IMRT using a 5000ppm fluoride paste daily.
Materials And Methods: Dental status/salivary protein data were obtained from 40 HNC patients pre-IMRT, six months (T1) and 12 months (T2) post-IMRT (ethical approval/consent). DMFT/salivary parameters were quantified, including flow rate, mucin 5B/7, Immunoglobulin A (IgA), cystatin S and α-amylase.
Article Synopsis
- The study investigates how the composition of salivary proteins relates to the onset and severity of oral mucositis (OM) in patients undergoing intensity-modulated radiotherapy (IMRT) for head and neck cancer.
- A longitudinal analysis was conducted on 40 patients, comparing saliva samples and clinical data before and after treatment, revealing that a significant majority experienced OM, and several salivary proteins were linked to OM outcomes.
- The findings suggest a potential for using specific salivary proteins as biomarkers for OM, paving the way for personalized medicine approaches to enhance patients' quality of life.