Publications by authors named "Sophie Rivara"
Article Synopsis
- STING is an important protein that activates immune responses during infections and diseases like cancer, but must be carefully regulated to avoid harmful inflammation.
- Once activated, STING moves within the cell and needs to be phosphorylated by TBK1 to trigger signaling, but how this signaling is turned off is not fully understood.
- Researchers found that AP-1 adaptor protein is key in stopping STING activity by sorting it for degradation, and they highlighted that specific structural features of STING and its phosphorylation play crucial roles in this process.
Two studies published in this issue of JEM, by Lepelley et al. (https://doi.org/10.
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