Publications by authors named "Sophie Pittion"
Introduction: No randomized controlled clinical trial of therapeutic plasma exchanges (TPE) has yet been performed for moderate-to-severe relapses of multiple sclerosis (MS).
Objective: To compare TPE to sham-TPE in patients with a recent steroid-resistant moderate-to-severe MS relapse.
Methods: Patients presenting with an MS relapse of less than 2 months without improvement and 15 days after a course of steroids were randomized.
Background: Therapeutic options are limited in secondary progressive multiple sclerosis (SPMS). Open-label studies suggested efficacy of monthly IV cyclophosphamide (CPM) without induction for delaying progression but no randomized trial was conducted so far.
Objective: To compare CPM to methylprednisolone (MP) in SPMS.
Myasthenia gravis is an autoimmune disorder affecting neuromuscular junctions that has been associated with a small increased risk of amyotrophic lateral sclerosis (ALS). Here, we describe a retrospective series of seven cases with a concomitant diagnosis of ALS and myasthenia gravis, collected among the 18 French reference centers for ALS in a twelve year period. After careful review, only six patients strictly met the diagnostic criteria for both ALS and myasthenia gravis.
View Article and Find Full Text PDFNeuromyelitis optica (NMO) is a life-threatening disease without any validated treatment strategy. Recent retrospective studies suggested the efficacy of B cell depletion without any distinction between first-line or rescue therapy. To assess whether rituximab as first-line therapy in NMO could efficiently control the occurrence of relapses.
View Article and Find Full Text PDFArticle Synopsis
- Inherited white matter diseases, previously thought to mainly affect infants, are increasingly recognized in adults, prompting researchers to study their prevalence and diagnostic effectiveness in adults over 16 years old.
- The study analyzed brain MRIs of 154 adult patients, finding distinct groups of leukoencephalopathies and achieving a diagnosis in 64% of cases.
- Key findings included the identification of specific genetic disorders, such as CADASIL and EIF2B-related disorders, highlighting the value of systematic diagnostic approaches in adult-onset cases.
Background: The clinical impact of neutralizing antibodies against interferon-beta (NAb) is controversial. Their presence can lead to a decrease in interferon-beta (IFNβ) efficacy. Fatigue reported in patients with multiple sclerosis (MS) may be associated with an unfavorable clinical course.
View Article and Find Full Text PDFBackground: As of yet, no consensus has been reached regarding cognitive impairment profiles in multiple sclerosis (MS) patients based on the MS type and disease duration. The main objective of this study was to describe cognitive impairment at the early stages of MS. The secondary objective was to compare cognitive performances in patients with relapsing remitting multiple sclerosis (RRMS), secondary progressive (SP) MS and primary progressive (PP) MS.
View Article and Find Full Text PDFBackground: Acute demyelinating encephalomyelitis (ADEM) is characterized by a severe inflammatory attack, frequently secondary to infectious events or vaccinations. To date, no clear criteria exist for ADEM, and the risk of subsequent evolution to multiple sclerosis (MS) remains unknown.
Objective: To evaluate the risk of evolution to MS after a first episode of ADEM.