Publications by authors named "Sophie Pfeiffer"
Objectives: B-cell depletion time after rituximab (RTX) treatment is prolonged in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) compared with other autoimmune diseases. We investigated central and peripheral B-cell development to identify the causes for the defect in B-cell reconstitution after RTX therapy.
Methods: We recruited 91 patients with AAV and performed deep phenotyping of the peripheral and bone marrow B-cell compartment by spectral flow and mass cytometry.
Article Synopsis
- Metastasis-directed therapy has potential benefits for patients with oligometastatic disease (OMD), but breast cancer studies have not yet confirmed these benefits through randomized trials.
- A study at the Technical University of Munich analyzed 80 patients using F-FDG PET/CT images to better define OMD, revealing that nearly half the time, this imaging method significantly changed the assessment of metastatic disease compared to conventional CT.
- F-FDG PET/CT discovered additional metastases in a third of cases, highlighting the need for clearer standards in imaging definitions for future research and clinical practices in breast cancer treatment.
Objective: We aimed to clarify the association of various HLA risk alleles with different types of autoantibodies initiating islet specific autoimmunity.
Methods: Follow-up cohorts from the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) study and children diagnosed with type 1 diabetes (T1D) from the Finnish Pediatric Diabetes Register (FPDR) were analyzed for the presence of autoantibodies to insulin (IAA), glutamic acid decarboxylase (GADA), IA-2 antigen (IA-2A), and zinc transporter 8 (ZnT8A); and genotyped for HLA DR/DQ alleles. In the DIPP study, autoantibodies were regularly analyzed from birth up to 15 years of age.