Publications by authors named "Sophie Munnings-Tomes"
Pediatric patients with high-risk neuroblastoma have poor survival rates and urgently need more effective treatment options with less side effects. Since novel and improved immunotherapies may fill this need, we dissect the immunoregulatory interactions in neuroblastoma by single-cell RNA-sequencing of 24 tumors (10 pre- and 14 post-chemotherapy, including 5 pairs) to identify strategies for optimizing immunotherapy efficacy. Neuroblastomas are infiltrated by natural killer (NK), T and B cells, and immunosuppressive myeloid populations.
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- Immuno-oncology treatments have become standard for many cancers, but only a few patients see lasting benefits, highlighting the need for biomarkers to predict which patients will respond.
- Researchers developed a new non-terminal biopsy method using fine needle aspiration to sample tumor tissue in mice without sacrificing them, allowing for repeated analysis.
- This innovative technique enables linking tumor microenvironment biomarkers to treatment outcomes, enhancing preclinical research while minimizing animal use.
Background: Docetaxel chemotherapy in prostate cancer has a modest impact on survival. To date, efforts to develop combination therapies have not translated into new treatments. We sought to develop a novel therapeutic strategy to tackle chemoresistant prostate cancer by enhancing the efficacy of docetaxel.
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